Targeting Ribosome Biogenesis in Cancer: Lessons Learned and Way Forward

Targeting Ribosome Biogenesis in Cancer: Lessons Learned and Way Forward

Rapid growth and unrestrained proliferation is a hallmark of many cancers. To accomplish this, cancer cells re-wire and increase their biosynthetic and metabolic activities, including ribosome biogenesis (RiBi), a complex, highly energy-consuming process. Several chemotherapeutic agents used in the...

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Bibliographic Details
Main Authors: Asimina Zisi, Jiri Bartek, Mikael S. Lindström
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cancers
Subjects:
ribosome biogenesis
nucleolus
p53
cancer
RNA polymerase I
translation
Online Access:https://www.mdpi.com/2072-6694/14/9/2126

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