| Summary: | Hepatocellular carcinoma (HCC) is a malignant digestive tract tumor with extremely high morbidity and mortality. In recent years, diagnosis and treatment of HCC have made significant improvements in China. New technologies such as single-cell sequencing, spatial-omics sequencing and deep learning-based artificial intelligence have led to breakthroughs in basic research of liver cancer. A more comprehensive understanding of the biological characteristics of HCC will push the breakthroughs in industry-university-research and clinical treatment and become the key to improving the treatment efficacy of HCC. With the publication of the results of several large-scale prospective clinical studies such as FOLFOX-HAIC, LEAP-002 and KEYNOTE-301, more possibilities for postoperative HCC and HCC patients with failure of first-line treatment have been opened up. Pushing the boundaries of local and systemic treatment options, new translational studies (TALENTop and IBI305) have further transformed intermediate to advanced hepatocellular carcinoma into surgically resectable disease, giving more patients with HCC the opportunity to be saved. This article summarized the basic and clinical research progress in the field of HCC in 2022.
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