Hypoxia independent drivers of melanoma angiogenesis
Tumor angiogenesis is a process which is traditionally regarded as the tumor`s response to low nutrient supply occurring under hypoxic conditions. However, hypoxia is not a prerequisite for angiogenesis. The fact that even single tumor cells or small tumor cell aggregates are capable of attracting b...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00102/full |
| _version_ | 1818504265320103936 |
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| author | Svenja eMeierjohann |
| author_facet | Svenja eMeierjohann |
| author_sort | Svenja eMeierjohann |
| collection | DOAJ |
| description | Tumor angiogenesis is a process which is traditionally regarded as the tumor`s response to low nutrient supply occurring under hypoxic conditions. However, hypoxia is not a prerequisite for angiogenesis. The fact that even single tumor cells or small tumor cell aggregates are capable of attracting blood vessels reveals the early metastatic capability of tumor cells. This review sheds light on the hypoxia independent mechanisms of tumor angiogenesis in melanoma. |
| first_indexed | 2024-12-10T21:34:53Z |
| format | Article |
| id | doaj.art-06aa1f42e1dd4798aff2e442c2a1034d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-10T21:34:53Z |
| publishDate | 2015-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-06aa1f42e1dd4798aff2e442c2a1034d2022-12-22T01:32:40ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2015-05-01510.3389/fonc.2015.00102137978Hypoxia independent drivers of melanoma angiogenesisSvenja eMeierjohann0University of WurzburgTumor angiogenesis is a process which is traditionally regarded as the tumor`s response to low nutrient supply occurring under hypoxic conditions. However, hypoxia is not a prerequisite for angiogenesis. The fact that even single tumor cells or small tumor cell aggregates are capable of attracting blood vessels reveals the early metastatic capability of tumor cells. This review sheds light on the hypoxia independent mechanisms of tumor angiogenesis in melanoma.http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00102/fullMelanomaReactive Oxygen SpeciesAngiogenesisNF-kBhypoxia-independent |
| spellingShingle | Svenja eMeierjohann Hypoxia independent drivers of melanoma angiogenesis Frontiers in Oncology Melanoma Reactive Oxygen Species Angiogenesis NF-kB hypoxia-independent |
| title | Hypoxia independent drivers of melanoma angiogenesis |
| title_full | Hypoxia independent drivers of melanoma angiogenesis |
| title_fullStr | Hypoxia independent drivers of melanoma angiogenesis |
| title_full_unstemmed | Hypoxia independent drivers of melanoma angiogenesis |
| title_short | Hypoxia independent drivers of melanoma angiogenesis |
| title_sort | hypoxia independent drivers of melanoma angiogenesis |
| topic | Melanoma Reactive Oxygen Species Angiogenesis NF-kB hypoxia-independent |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00102/full |
| work_keys_str_mv | AT svenjaemeierjohann hypoxiaindependentdriversofmelanomaangiogenesis |