Role of Phosphorus-Containing Molecules on the Formation of Nano-Sized Calcium Phosphate for Bone Therapy
Calcium phosphate (CaP) is the principal inorganic constituent of bone and teeth in vertebrates and has various applications in biomedical areas. Among various types of CaPs, amorphous calcium phosphate (ACP) is considered to have superior bioactivity and biodegradability. With regard to the instabi...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.875531/full |
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| author | Yingying Jiang Yingying Jiang Yali Tao Yutong Chen Xu Xue Gangyi Ding Sicheng Wang Sicheng Wang Guodong Liu Mengmeng Li Jiacan Su Jiacan Su |
| author_facet | Yingying Jiang Yingying Jiang Yali Tao Yutong Chen Xu Xue Gangyi Ding Sicheng Wang Sicheng Wang Guodong Liu Mengmeng Li Jiacan Su Jiacan Su |
| author_sort | Yingying Jiang |
| collection | DOAJ |
| description | Calcium phosphate (CaP) is the principal inorganic constituent of bone and teeth in vertebrates and has various applications in biomedical areas. Among various types of CaPs, amorphous calcium phosphate (ACP) is considered to have superior bioactivity and biodegradability. With regard to the instability of ACP, the phosphorus-containing molecules are usually adopted to solve this issue, but the specific roles of the molecules in the formation of nano-sized CaP have not been clearly clarified yet. Herein, alendronate, cyclophosphamide, zoledronate, and foscarnet are selected as the model molecules, and theoretical calculations were performed to elucidate the interaction between calcium ions and different model molecules. Subsequently, CaPs were prepared with the addition of the phosphorus-containing molecules. It is found that cyclophosphamide has limited influence on the generation of CaPs due to their weak interaction. During the co-precipitation process of Ca2+ and PO43-, the competitive relation among alendronate, zoledronate, and foscarnet plays critical roles in the produced inorganic-organic complex. Moreover, the biocompatibility of CaPs was also systematically evaluated. The DFT calculation provides a convincing strategy for predicting the structure of CaPs with various additives. This work is promising for designing CaP-based multifunctional drug delivery systems and tissue engineering materials. |
| first_indexed | 2024-12-12T11:55:04Z |
| format | Article |
| id | doaj.art-06aa830d180a4084aabb426935b6b52c |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-12T11:55:04Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-06aa830d180a4084aabb426935b6b52c2022-12-22T00:25:12ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-06-011010.3389/fbioe.2022.875531875531Role of Phosphorus-Containing Molecules on the Formation of Nano-Sized Calcium Phosphate for Bone TherapyYingying Jiang0Yingying Jiang1Yali Tao2Yutong Chen3Xu Xue4Gangyi Ding5Sicheng Wang6Sicheng Wang7Guodong Liu8Mengmeng Li9Jiacan Su10Jiacan Su11Institute of Translational Medicine, Shanghai University, Shanghai, ChinaDepartment of Orthopedic, Spinal Pain Research Institute, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai, ChinaDepartment of Orthopedics Trauma, Shanghai Zhongye Hospital, Shanghai, ChinaWound Care Center, Daping Hospital, Army Medical Center of PLA, Chongqing, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai, ChinaDepartment of Trauma Orthopedics, Changhai Hospital, Naval Medical University, Shanghai, ChinaCalcium phosphate (CaP) is the principal inorganic constituent of bone and teeth in vertebrates and has various applications in biomedical areas. Among various types of CaPs, amorphous calcium phosphate (ACP) is considered to have superior bioactivity and biodegradability. With regard to the instability of ACP, the phosphorus-containing molecules are usually adopted to solve this issue, but the specific roles of the molecules in the formation of nano-sized CaP have not been clearly clarified yet. Herein, alendronate, cyclophosphamide, zoledronate, and foscarnet are selected as the model molecules, and theoretical calculations were performed to elucidate the interaction between calcium ions and different model molecules. Subsequently, CaPs were prepared with the addition of the phosphorus-containing molecules. It is found that cyclophosphamide has limited influence on the generation of CaPs due to their weak interaction. During the co-precipitation process of Ca2+ and PO43-, the competitive relation among alendronate, zoledronate, and foscarnet plays critical roles in the produced inorganic-organic complex. Moreover, the biocompatibility of CaPs was also systematically evaluated. The DFT calculation provides a convincing strategy for predicting the structure of CaPs with various additives. This work is promising for designing CaP-based multifunctional drug delivery systems and tissue engineering materials.https://www.frontiersin.org/articles/10.3389/fbioe.2022.875531/fullphosphorus-containing moleculescalcium phosphatenanocompositesbone therapydrug delivery |
| spellingShingle | Yingying Jiang Yingying Jiang Yali Tao Yutong Chen Xu Xue Gangyi Ding Sicheng Wang Sicheng Wang Guodong Liu Mengmeng Li Jiacan Su Jiacan Su Role of Phosphorus-Containing Molecules on the Formation of Nano-Sized Calcium Phosphate for Bone Therapy Frontiers in Bioengineering and Biotechnology phosphorus-containing molecules calcium phosphate nanocomposites bone therapy drug delivery |
| title | Role of Phosphorus-Containing Molecules on the Formation of Nano-Sized Calcium Phosphate for Bone Therapy |
| title_full | Role of Phosphorus-Containing Molecules on the Formation of Nano-Sized Calcium Phosphate for Bone Therapy |
| title_fullStr | Role of Phosphorus-Containing Molecules on the Formation of Nano-Sized Calcium Phosphate for Bone Therapy |
| title_full_unstemmed | Role of Phosphorus-Containing Molecules on the Formation of Nano-Sized Calcium Phosphate for Bone Therapy |
| title_short | Role of Phosphorus-Containing Molecules on the Formation of Nano-Sized Calcium Phosphate for Bone Therapy |
| title_sort | role of phosphorus containing molecules on the formation of nano sized calcium phosphate for bone therapy |
| topic | phosphorus-containing molecules calcium phosphate nanocomposites bone therapy drug delivery |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.875531/full |
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