Study on Deposition Characteristics of Microparticles in Terminal Pulmonary Acini by IB–LBM
As an indicator of health risk, the deposition of microparticles in terminal pulmonary acini is of great significance in the medical field. To control particulate pollution and optimize aerosol delivery, it is necessary to perform an in-depth study of the microparticle deposition in terminal pulmona...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/12/8/957 |
| _version_ | 1797522819583574016 |
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| author | Du-Chang Xu Yu-Xiao Luo Yuan-Qing Xu |
| author_facet | Du-Chang Xu Yu-Xiao Luo Yuan-Qing Xu |
| author_sort | Du-Chang Xu |
| collection | DOAJ |
| description | As an indicator of health risk, the deposition of microparticles in terminal pulmonary acini is of great significance in the medical field. To control particulate pollution and optimize aerosol delivery, it is necessary to perform an in-depth study of the microparticle deposition in terminal pulmonary acini; however, little research has been done on this topic. This paper proposes a respiratory movement model of terminal pulmonary acini using an immersed boundary–lattice Boltzmann method. In addition, we explored the effect of gravity direction, respiratory rate, microparticle diameter, and other parameters on the microparticles deposition process and distribution, under the airflow in the acinar wall. It was found that the deposition of microparticles is sensitive to gravity direction, and the growth of the respiratory rate increases the rate of microparticle migration and deposition. It was observed that the gravity effect is enhanced by increasing the diameter of microparticles, causing a high deposition and dispersion rate. The study reveals the dynamic correlation between the respiration process and the movement of microparticles, which is of reference value to figure out the pathogenicity mechanism of inhalable particles and to optimize the aerosol delivery. |
| first_indexed | 2024-03-10T08:34:46Z |
| format | Article |
| id | doaj.art-06aac0b4e89247849b42c7fefd55df26 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T08:34:46Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-06aac0b4e89247849b42c7fefd55df262023-11-22T08:44:37ZengMDPI AGMicromachines2072-666X2021-08-0112895710.3390/mi12080957Study on Deposition Characteristics of Microparticles in Terminal Pulmonary Acini by IB–LBMDu-Chang Xu0Yu-Xiao Luo1Yuan-Qing Xu2School of Life Science, Beijing Institute of Technology, Beijing 100081, ChinaUniversity Medical Center Göttingen, University of Göttingen, 37075 Göttingen, GermanySchool of Life Science, Beijing Institute of Technology, Beijing 100081, ChinaAs an indicator of health risk, the deposition of microparticles in terminal pulmonary acini is of great significance in the medical field. To control particulate pollution and optimize aerosol delivery, it is necessary to perform an in-depth study of the microparticle deposition in terminal pulmonary acini; however, little research has been done on this topic. This paper proposes a respiratory movement model of terminal pulmonary acini using an immersed boundary–lattice Boltzmann method. In addition, we explored the effect of gravity direction, respiratory rate, microparticle diameter, and other parameters on the microparticles deposition process and distribution, under the airflow in the acinar wall. It was found that the deposition of microparticles is sensitive to gravity direction, and the growth of the respiratory rate increases the rate of microparticle migration and deposition. It was observed that the gravity effect is enhanced by increasing the diameter of microparticles, causing a high deposition and dispersion rate. The study reveals the dynamic correlation between the respiration process and the movement of microparticles, which is of reference value to figure out the pathogenicity mechanism of inhalable particles and to optimize the aerosol delivery.https://www.mdpi.com/2072-666X/12/8/957microparticles depositionterminal pulmonary aciniIB–LBM |
| spellingShingle | Du-Chang Xu Yu-Xiao Luo Yuan-Qing Xu Study on Deposition Characteristics of Microparticles in Terminal Pulmonary Acini by IB–LBM Micromachines microparticles deposition terminal pulmonary acini IB–LBM |
| title | Study on Deposition Characteristics of Microparticles in Terminal Pulmonary Acini by IB–LBM |
| title_full | Study on Deposition Characteristics of Microparticles in Terminal Pulmonary Acini by IB–LBM |
| title_fullStr | Study on Deposition Characteristics of Microparticles in Terminal Pulmonary Acini by IB–LBM |
| title_full_unstemmed | Study on Deposition Characteristics of Microparticles in Terminal Pulmonary Acini by IB–LBM |
| title_short | Study on Deposition Characteristics of Microparticles in Terminal Pulmonary Acini by IB–LBM |
| title_sort | study on deposition characteristics of microparticles in terminal pulmonary acini by ib lbm |
| topic | microparticles deposition terminal pulmonary acini IB–LBM |
| url | https://www.mdpi.com/2072-666X/12/8/957 |
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