Peptides Targeting HER2-Positive Breast Cancer Cells and Applications in Tumor Imaging and Delivery of Chemotherapeutics
Breast cancer represents the most common cancer type and one of the major leading causes of death in the female worldwide population. Overexpression of HER2, a transmembrane glycoprotein related to the epidermal growth factor receptor, results in a biologically and clinically aggressive breast cance...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/13/17/2476 |
| _version_ | 1797582025222258688 |
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| author | Palmira Alessia Cavallaro Marzia De Santo Emilia Lucia Belsito Camilla Longobucco Manuela Curcio Catia Morelli Luigi Pasqua Antonella Leggio |
| author_facet | Palmira Alessia Cavallaro Marzia De Santo Emilia Lucia Belsito Camilla Longobucco Manuela Curcio Catia Morelli Luigi Pasqua Antonella Leggio |
| author_sort | Palmira Alessia Cavallaro |
| collection | DOAJ |
| description | Breast cancer represents the most common cancer type and one of the major leading causes of death in the female worldwide population. Overexpression of HER2, a transmembrane glycoprotein related to the epidermal growth factor receptor, results in a biologically and clinically aggressive breast cancer subtype. It is also the primary driver for tumor detection and progression and, in addition to being an important prognostic factor in women diagnosed with breast cancer, HER2 is a widely known therapeutic target for drug development. The aim of this review is to provide an updated overview of the main approaches for the diagnosis and treatment of HER2-positive breast cancer proposed in the literature over the past decade. We focused on the different targeting strategies involving antibodies and peptides that have been explored with their relative outcomes and current limitations that need to be improved. The review also encompasses a discussion on targeted peptides acting as probes for molecular imaging. By using different types of HER2-targeting strategies, nanotechnology promises to overcome some of the current clinical challenges by developing novel HER2-guided nanosystems suitable as powerful tools in breast cancer imaging, targeting, and therapy. |
| first_indexed | 2024-03-10T23:15:59Z |
| format | Article |
| id | doaj.art-06ab388ed2b94cad9f2906fe1ca4bad9 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T23:15:59Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-06ab388ed2b94cad9f2906fe1ca4bad92023-11-19T08:37:13ZengMDPI AGNanomaterials2079-49912023-09-011317247610.3390/nano13172476Peptides Targeting HER2-Positive Breast Cancer Cells and Applications in Tumor Imaging and Delivery of ChemotherapeuticsPalmira Alessia Cavallaro0Marzia De Santo1Emilia Lucia Belsito2Camilla Longobucco3Manuela Curcio4Catia Morelli5Luigi Pasqua6Antonella Leggio7Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Rende, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Rende, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Rende, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Rende, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Rende, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Rende, ItalyDepartment of Environmental Engineering, University of Calabria, Via P. Bucci, 87036 Rende, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Rende, ItalyBreast cancer represents the most common cancer type and one of the major leading causes of death in the female worldwide population. Overexpression of HER2, a transmembrane glycoprotein related to the epidermal growth factor receptor, results in a biologically and clinically aggressive breast cancer subtype. It is also the primary driver for tumor detection and progression and, in addition to being an important prognostic factor in women diagnosed with breast cancer, HER2 is a widely known therapeutic target for drug development. The aim of this review is to provide an updated overview of the main approaches for the diagnosis and treatment of HER2-positive breast cancer proposed in the literature over the past decade. We focused on the different targeting strategies involving antibodies and peptides that have been explored with their relative outcomes and current limitations that need to be improved. The review also encompasses a discussion on targeted peptides acting as probes for molecular imaging. By using different types of HER2-targeting strategies, nanotechnology promises to overcome some of the current clinical challenges by developing novel HER2-guided nanosystems suitable as powerful tools in breast cancer imaging, targeting, and therapy.https://www.mdpi.com/2079-4991/13/17/2476targeting peptidesHER2-positive breast cancermonoclonal antibodiesnanoparticlesdrug deliverytumor imaging |
| spellingShingle | Palmira Alessia Cavallaro Marzia De Santo Emilia Lucia Belsito Camilla Longobucco Manuela Curcio Catia Morelli Luigi Pasqua Antonella Leggio Peptides Targeting HER2-Positive Breast Cancer Cells and Applications in Tumor Imaging and Delivery of Chemotherapeutics Nanomaterials targeting peptides HER2-positive breast cancer monoclonal antibodies nanoparticles drug delivery tumor imaging |
| title | Peptides Targeting HER2-Positive Breast Cancer Cells and Applications in Tumor Imaging and Delivery of Chemotherapeutics |
| title_full | Peptides Targeting HER2-Positive Breast Cancer Cells and Applications in Tumor Imaging and Delivery of Chemotherapeutics |
| title_fullStr | Peptides Targeting HER2-Positive Breast Cancer Cells and Applications in Tumor Imaging and Delivery of Chemotherapeutics |
| title_full_unstemmed | Peptides Targeting HER2-Positive Breast Cancer Cells and Applications in Tumor Imaging and Delivery of Chemotherapeutics |
| title_short | Peptides Targeting HER2-Positive Breast Cancer Cells and Applications in Tumor Imaging and Delivery of Chemotherapeutics |
| title_sort | peptides targeting her2 positive breast cancer cells and applications in tumor imaging and delivery of chemotherapeutics |
| topic | targeting peptides HER2-positive breast cancer monoclonal antibodies nanoparticles drug delivery tumor imaging |
| url | https://www.mdpi.com/2079-4991/13/17/2476 |
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