Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma
EGFR mutations in lung adenocarcinoma are more frequent in East Asians compared to other populations. Here, the authors carry out a genome-wide association study in EGFRmutant cancers and identify loci that are associated with risk of developing this molecular subtype of cancer.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12451 |
| _version_ | 1819129763501965312 |
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| author | Kouya Shiraishi Yukinori Okada Atsushi Takahashi Yoichiro Kamatani Yukihide Momozawa Kyota Ashikawa Hideo Kunitoh Shingo Matsumoto Atsushi Takano Kimihiro Shimizu Akiteru Goto Koji Tsuta Shun-ichi Watanabe Yuichiro Ohe Yukio Watanabe Yasushi Goto Hiroshi Nokihara Koh Furuta Akihiko Yoshida Koichi Goto Tomoyuki Hishida Masahiro Tsuboi Katsuya Tsuchihara Yohei Miyagi Haruhiko Nakayama Tomoyuki Yokose Kazumi Tanaka Toshiteru Nagashima Yoichi Ohtaki Daichi Maeda Kazuhiro Imai Yoshihiro Minamiya Hiromi Sakamoto Akira Saito Yoko Shimada Kuniko Sunami Motonobu Saito Johji Inazawa Yusuke Nakamura Teruhiko Yoshida Jun Yokota Fumihiko Matsuda Keitaro Matsuo Yataro Daigo Michiaki Kubo Takashi Kohno |
| author_facet | Kouya Shiraishi Yukinori Okada Atsushi Takahashi Yoichiro Kamatani Yukihide Momozawa Kyota Ashikawa Hideo Kunitoh Shingo Matsumoto Atsushi Takano Kimihiro Shimizu Akiteru Goto Koji Tsuta Shun-ichi Watanabe Yuichiro Ohe Yukio Watanabe Yasushi Goto Hiroshi Nokihara Koh Furuta Akihiko Yoshida Koichi Goto Tomoyuki Hishida Masahiro Tsuboi Katsuya Tsuchihara Yohei Miyagi Haruhiko Nakayama Tomoyuki Yokose Kazumi Tanaka Toshiteru Nagashima Yoichi Ohtaki Daichi Maeda Kazuhiro Imai Yoshihiro Minamiya Hiromi Sakamoto Akira Saito Yoko Shimada Kuniko Sunami Motonobu Saito Johji Inazawa Yusuke Nakamura Teruhiko Yoshida Jun Yokota Fumihiko Matsuda Keitaro Matsuo Yataro Daigo Michiaki Kubo Takashi Kohno |
| author_sort | Kouya Shiraishi |
| collection | DOAJ |
| description | EGFR mutations in lung adenocarcinoma are more frequent in East Asians compared to other populations. Here, the authors carry out a genome-wide association study in EGFRmutant cancers and identify loci that are associated with risk of developing this molecular subtype of cancer. |
| first_indexed | 2024-12-22T08:48:53Z |
| format | Article |
| id | doaj.art-06abe374e88a4c0f861cb8193ced8a5f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T08:48:53Z |
| publishDate | 2016-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-06abe374e88a4c0f861cb8193ced8a5f2022-12-21T18:32:01ZengNature PortfolioNature Communications2041-17232016-08-01711710.1038/ncomms12451Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinomaKouya Shiraishi0Yukinori Okada1Atsushi Takahashi2Yoichiro Kamatani3Yukihide Momozawa4Kyota Ashikawa5Hideo Kunitoh6Shingo Matsumoto7Atsushi Takano8Kimihiro Shimizu9Akiteru Goto10Koji Tsuta11Shun-ichi Watanabe12Yuichiro Ohe13Yukio Watanabe14Yasushi Goto15Hiroshi Nokihara16Koh Furuta17Akihiko Yoshida18Koichi Goto19Tomoyuki Hishida20Masahiro Tsuboi21Katsuya Tsuchihara22Yohei Miyagi23Haruhiko Nakayama24Tomoyuki Yokose25Kazumi Tanaka26Toshiteru Nagashima27Yoichi Ohtaki28Daichi Maeda29Kazuhiro Imai30Yoshihiro Minamiya31Hiromi Sakamoto32Akira Saito33Yoko Shimada34Kuniko Sunami35Motonobu Saito36Johji Inazawa37Yusuke Nakamura38Teruhiko Yoshida39Jun Yokota40Fumihiko Matsuda41Keitaro Matsuo42Yataro Daigo43Michiaki Kubo44Takashi Kohno45Division of Genome Biology, National Cancer Center Research InstituteDepartment of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental UniversityLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical SciencesLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical SciencesLaboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKENLaboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKENDepartment of Medical Oncology, Japanese Red Cross Medical CenterDivision of Translational Research, Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center Research InstituteCenter for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of TokyoDepartment of Integrative Center of General Surgery, Gunma University HospitalDepartment of Cellular and Organ Pathology, Graduate School of Medicine, Akita UniversityDepartment of Pathology, National Cancer Center HospitalDivision of Thoracic Surgery, National Cancer Centre HospitalDepartment of Thoracic Oncology, National Cancer Center HospitalDivision of Thoracic Surgery, National Cancer Centre HospitalDepartment of Thoracic Oncology, National Cancer Center HospitalDepartment of Thoracic Oncology, National Cancer Center HospitalDepartment of Clinical Laboratories, National Cancer Center HospitalDepartment of Pathology, National Cancer Center HospitalDepartment of Thoracic Oncology, National Cancer Center Hospital EastDepartment of Thoracic Surgery, National Cancer Center Hospital EastDepartment of Thoracic Surgery, National Cancer Center Hospital EastDivision of Translational Research, Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center Research InstituteMolecular Pathology and Genetics Division, Kanagawa Cancer Center Research InstituteDepartment of Thoracic Surgery, Kanagawa Cancer CenterDepartment of Pathology, Kanagawa Cancer CenterDepartment of Integrative Center of General Surgery, Gunma University HospitalDepartment of Integrative Center of General Surgery, Gunma University HospitalDepartment of Integrative Center of General Surgery, Gunma University HospitalDepartment of Cellular and Organ Pathology, Graduate School of Medicine, Akita UniversityDepartment of Thoracic Surgery, Graduate School of Medicine, Akita UniversityDepartment of Thoracic Surgery, Graduate School of Medicine, Akita UniversityDivision of Genetics, National Cancer Center Research InstituteStaGen Co., Ltd.Division of Genome Biology, National Cancer Center Research InstituteDivision of Genome Biology, National Cancer Center Research InstituteDivision of Genome Biology, National Cancer Center Research InstituteDepartment of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental UniversityDepartment of Medicine and Department of Surgery, Center for Personalized Therapeutics, The University of ChicagoDivision of Genetics, National Cancer Center Research InstituteGenomics and Epigenomics of Cancer Prediction Program, Institute of Predictive and Personalized Medicine of Cancer (IMPPC)Center for Genomic Medicine, Graduate School of Medicine, Kyoto UniversityDivision of Division of Molecular Medicine, Aichi Cancer Center Research InstituteCenter for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of TokyoLaboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKENDivision of Genome Biology, National Cancer Center Research InstituteEGFR mutations in lung adenocarcinoma are more frequent in East Asians compared to other populations. Here, the authors carry out a genome-wide association study in EGFRmutant cancers and identify loci that are associated with risk of developing this molecular subtype of cancer.https://doi.org/10.1038/ncomms12451 |
| spellingShingle | Kouya Shiraishi Yukinori Okada Atsushi Takahashi Yoichiro Kamatani Yukihide Momozawa Kyota Ashikawa Hideo Kunitoh Shingo Matsumoto Atsushi Takano Kimihiro Shimizu Akiteru Goto Koji Tsuta Shun-ichi Watanabe Yuichiro Ohe Yukio Watanabe Yasushi Goto Hiroshi Nokihara Koh Furuta Akihiko Yoshida Koichi Goto Tomoyuki Hishida Masahiro Tsuboi Katsuya Tsuchihara Yohei Miyagi Haruhiko Nakayama Tomoyuki Yokose Kazumi Tanaka Toshiteru Nagashima Yoichi Ohtaki Daichi Maeda Kazuhiro Imai Yoshihiro Minamiya Hiromi Sakamoto Akira Saito Yoko Shimada Kuniko Sunami Motonobu Saito Johji Inazawa Yusuke Nakamura Teruhiko Yoshida Jun Yokota Fumihiko Matsuda Keitaro Matsuo Yataro Daigo Michiaki Kubo Takashi Kohno Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma Nature Communications |
| title | Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma |
| title_full | Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma |
| title_fullStr | Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma |
| title_full_unstemmed | Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma |
| title_short | Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma |
| title_sort | association of variations in hla class ii and other loci with susceptibility to egfr mutated lung adenocarcinoma |
| url | https://doi.org/10.1038/ncomms12451 |
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