Lung immunoglobulin A immunity dysregulation in cystic fibrosis

Lung immunoglobulin A immunity dysregulation in cystic fibrosis

Background: In cystic fibrosis (CF), recurrent infections suggest impaired mucosal immunity but whether production of secretory immunoglobulin A (S-IgA) is impaired remains elusive. S-IgA is generated following polymeric immunoglobulin receptor (pIgR)-mediated transepithelial transport of dimeric (d...

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Bibliographic Details
Main Authors: Amandine M. Collin, Marylène Lecocq, Sabrina Noel, Bruno Detry, François M. Carlier, Frank Aboubakar Nana, Caroline Bouzin, Teresinha Leal, Marjorie Vermeersch, Virginia De Rose, Lucile Regard, Clémence Martin, Pierre-Régis Burgel, Delphine Hoton, Stijn Verleden, Antoine Froidure, Charles Pilette, Sophie Gohy
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:EBioMedicine
Subjects:
Cystic fibrosis
Immunoglobulin A
Lung mucosal immunity
Infection
Endoplasmic reticulum stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420303509

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