Anastomotic stenosis of bioengineered trachea grafts is driven by transforming growth factor β1-induced signaling, proinflammatory macrophages, and delayed epithelializationCentral MessagePerspective

Anastomotic stenosis of bioengineered trachea grafts is driven by transforming growth factor β1-induced signaling, proinflammatory macrophages, and delayed epithelializationCentral MessagePerspective

Objective: Anastomotic stenosis caused by hypertrophic granulation tissue often develops in response to orthotopically implanted bioengineered tracheal grafts. To determine mechanisms responsible for the development and persistence of this granulation tissue, we looked for changes in gene expression...

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Bibliographic Details
Main Authors: Joanna Weber, PhD, Russell Seth Martins, MD, Zaid Muslim, MD, Mirza Zain Baig, MD, Kostantinos Poulikidis, MD, Al Haitham Al Shetawi, MD, DMD, FACS, Faiz Y. Bhora, MD, FACS
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:JTCVS Open
Subjects:
tissue engineering
trachea
granulation tissue
stenosis
inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2666273623002036

Internet

http://www.sciencedirect.com/science/article/pii/S2666273623002036

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