The evolutionary mechanism of non-carbapenemase carbapenem-resistant phenotypes in Klebsiella spp

The evolutionary mechanism of non-carbapenemase carbapenem-resistant phenotypes in Klebsiella spp

Antibiotic resistance is driven by selection, but the degree to which a bacterial strain’s evolutionary history shapes the mechanism and strength of resistance remains an open question. Here, we reconstruct the genetic and evolutionary mechanisms of carbapenem resistance in a clinical isolate of Kle...

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Bibliographic Details
Main Authors: Natalia C Rosas, Jonathan Wilksch, Jake Barber, Jiahui Li, Yanan Wang, Zhewei Sun, Andrea Rocker, Chaille T Webb, Laura Perlaza-Jiménez, Christopher J Stubenrauch, Vijaykrishna Dhanasekaran, Jiangning Song, George Taiaroa, Mark Davies, Richard A Strugnell, Qiyu Bao, Tieli Zhou, Michael J McDonald, Trevor Lithgow
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-07-01
Series:eLife
Subjects:
antimicrobial resistance
non-carbapenemase carbapenem resistance
Klebsiella quasipneumoniae
Online Access:https://elifesciences.org/articles/83107

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