Case report: Metastatic metaplastic breast cancer with choriocarinomatous features: Targeting the choriocarcinoma component for cure
Breast cancer with choriocarcinomatous features (BCCF) is a rare and aggressive breast cancer. BCCF carries a poor prognosis and there is unfortunately scant literature to guide treatment beyond surgical resection with most patients receiving standard regimens for breast cancer. In our case, we pres...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1061679/full |
| _version_ | 1797960325422645248 |
|---|---|
| author | Krisha K. Mehta Rosa Nouvini Jingxuan Liu Yi Wang Alison Stopeck |
| author_facet | Krisha K. Mehta Rosa Nouvini Jingxuan Liu Yi Wang Alison Stopeck |
| author_sort | Krisha K. Mehta |
| collection | DOAJ |
| description | Breast cancer with choriocarcinomatous features (BCCF) is a rare and aggressive breast cancer. BCCF carries a poor prognosis and there is unfortunately scant literature to guide treatment beyond surgical resection with most patients receiving standard regimens for breast cancer. In our case, we present a 42-year-old female with an initial hCG of 2,324 and two suspicious lesions of the right breast. On biopsy, each lesion had distinct histopathology with the larger lesion diagnosed as BCCF and the smaller lesion being an invasive ER/PR positive ductal carcinoma. The diagnosis of BCCF rather than metastatic choriocarcinoma was confirmed using DNA typing. Salvage chemotherapy targeting choriocarcinoma resulted in marked clinical and biomarker success including normalization of the hCG. After recurrent brain metastases were diagnosed, high dose chemotherapy with methotrexate was administered resulting in long term remission. |
| first_indexed | 2024-04-11T00:44:14Z |
| format | Article |
| id | doaj.art-06b36244c7f04727a79a59a35af0655e |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T00:44:14Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-06b36244c7f04727a79a59a35af0655e2023-01-05T18:11:28ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-01-011210.3389/fonc.2022.10616791061679Case report: Metastatic metaplastic breast cancer with choriocarinomatous features: Targeting the choriocarcinoma component for cureKrisha K. Mehta0Rosa Nouvini1Jingxuan Liu2Yi Wang3Alison Stopeck4Department of Medicine, Stony Brook University, Stony Brook, NY, United StatesDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesDepartment of Pathology, Stony Brook University, Stony Brook, NY, United StatesDepartment of Pathology, Stony Brook University, Stony Brook, NY, United StatesDepartment of Medicine, Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, United StatesBreast cancer with choriocarcinomatous features (BCCF) is a rare and aggressive breast cancer. BCCF carries a poor prognosis and there is unfortunately scant literature to guide treatment beyond surgical resection with most patients receiving standard regimens for breast cancer. In our case, we present a 42-year-old female with an initial hCG of 2,324 and two suspicious lesions of the right breast. On biopsy, each lesion had distinct histopathology with the larger lesion diagnosed as BCCF and the smaller lesion being an invasive ER/PR positive ductal carcinoma. The diagnosis of BCCF rather than metastatic choriocarcinoma was confirmed using DNA typing. Salvage chemotherapy targeting choriocarcinoma resulted in marked clinical and biomarker success including normalization of the hCG. After recurrent brain metastases were diagnosed, high dose chemotherapy with methotrexate was administered resulting in long term remission.https://www.frontiersin.org/articles/10.3389/fonc.2022.1061679/fullbreast cancer with choriocarcinomatous featureschoriocarcinomametaplastic breast cancerchemotherapymethrotrexatelong term remission |
| spellingShingle | Krisha K. Mehta Rosa Nouvini Jingxuan Liu Yi Wang Alison Stopeck Case report: Metastatic metaplastic breast cancer with choriocarinomatous features: Targeting the choriocarcinoma component for cure Frontiers in Oncology breast cancer with choriocarcinomatous features choriocarcinoma metaplastic breast cancer chemotherapy methrotrexate long term remission |
| title | Case report: Metastatic metaplastic breast cancer with choriocarinomatous features: Targeting the choriocarcinoma component for cure |
| title_full | Case report: Metastatic metaplastic breast cancer with choriocarinomatous features: Targeting the choriocarcinoma component for cure |
| title_fullStr | Case report: Metastatic metaplastic breast cancer with choriocarinomatous features: Targeting the choriocarcinoma component for cure |
| title_full_unstemmed | Case report: Metastatic metaplastic breast cancer with choriocarinomatous features: Targeting the choriocarcinoma component for cure |
| title_short | Case report: Metastatic metaplastic breast cancer with choriocarinomatous features: Targeting the choriocarcinoma component for cure |
| title_sort | case report metastatic metaplastic breast cancer with choriocarinomatous features targeting the choriocarcinoma component for cure |
| topic | breast cancer with choriocarcinomatous features choriocarcinoma metaplastic breast cancer chemotherapy methrotrexate long term remission |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1061679/full |
| work_keys_str_mv | AT krishakmehta casereportmetastaticmetaplasticbreastcancerwithchoriocarinomatousfeaturestargetingthechoriocarcinomacomponentforcure AT rosanouvini casereportmetastaticmetaplasticbreastcancerwithchoriocarinomatousfeaturestargetingthechoriocarcinomacomponentforcure AT jingxuanliu casereportmetastaticmetaplasticbreastcancerwithchoriocarinomatousfeaturestargetingthechoriocarcinomacomponentforcure AT yiwang casereportmetastaticmetaplasticbreastcancerwithchoriocarinomatousfeaturestargetingthechoriocarcinomacomponentforcure AT alisonstopeck casereportmetastaticmetaplasticbreastcancerwithchoriocarinomatousfeaturestargetingthechoriocarcinomacomponentforcure |