Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy
Abstract Insulin-like growth factors (IGFs) play important roles in mammalian growth, development, aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and tumor progression, thus providing the rationale for targeting IGF axis in cancer. However, clinical trials of the t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13045-020-00904-3 |
| _version_ | 1819060228858052608 |
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| author | Hui Hua Qingbin Kong Jie Yin Jin Zhang Yangfu Jiang |
| author_facet | Hui Hua Qingbin Kong Jie Yin Jin Zhang Yangfu Jiang |
| author_sort | Hui Hua |
| collection | DOAJ |
| description | Abstract Insulin-like growth factors (IGFs) play important roles in mammalian growth, development, aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and tumor progression, thus providing the rationale for targeting IGF axis in cancer. However, clinical trials of the type I IGF receptor (IGF-IR)-targeted agents have been largely disappointing. Accumulating evidence demonstrates that the IGF axis not only promotes tumorigenesis, but also confers resistance to standard treatments. Furthermore, there are diverse pathways leading to the resistance to IGF-IR-targeted therapy. Recent studies characterizing the complex IGFs signaling in cancer have raised hope to refine the strategies for targeting the IGF axis. This review highlights the biological activities of IGF-IR signaling in cancer and the contribution of IGF-IR to cytotoxic, endocrine, and molecular targeted therapies resistance. Moreover, we update the diverse mechanisms underlying resistance to IGF-IR-targeted agents and discuss the strategies for future development of the IGF axis-targeted agents. |
| first_indexed | 2024-12-21T14:23:40Z |
| format | Article |
| id | doaj.art-06b4649cf99c46b3b9e47959cf51443a |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-12-21T14:23:40Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-06b4649cf99c46b3b9e47959cf51443a2022-12-21T19:00:42ZengBMCJournal of Hematology & Oncology1756-87222020-06-0113111710.1186/s13045-020-00904-3Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapyHui Hua0Qingbin Kong1Jie Yin2Jin Zhang3Yangfu Jiang4State Key Laboratory of Biotherapy, Laboratory of Stem Cell Biology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityState Key Laboratory of Biotherapy, Laboratory of Oncogene, Cancer Center, West China Hospital, Sichuan UniversityState Key Laboratory of Biotherapy, Laboratory of Oncogene, Cancer Center, West China Hospital, Sichuan UniversityState Key Laboratory of Biotherapy, Laboratory of Oncogene, Cancer Center, West China Hospital, Sichuan UniversityState Key Laboratory of Biotherapy, Laboratory of Oncogene, Cancer Center, West China Hospital, Sichuan UniversityAbstract Insulin-like growth factors (IGFs) play important roles in mammalian growth, development, aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and tumor progression, thus providing the rationale for targeting IGF axis in cancer. However, clinical trials of the type I IGF receptor (IGF-IR)-targeted agents have been largely disappointing. Accumulating evidence demonstrates that the IGF axis not only promotes tumorigenesis, but also confers resistance to standard treatments. Furthermore, there are diverse pathways leading to the resistance to IGF-IR-targeted therapy. Recent studies characterizing the complex IGFs signaling in cancer have raised hope to refine the strategies for targeting the IGF axis. This review highlights the biological activities of IGF-IR signaling in cancer and the contribution of IGF-IR to cytotoxic, endocrine, and molecular targeted therapies resistance. Moreover, we update the diverse mechanisms underlying resistance to IGF-IR-targeted agents and discuss the strategies for future development of the IGF axis-targeted agents.http://link.springer.com/article/10.1186/s13045-020-00904-3Insulin-like growth factorCancerReceptor tyrosine kinaseTumorigenesisDrug resistance |
| spellingShingle | Hui Hua Qingbin Kong Jie Yin Jin Zhang Yangfu Jiang Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy Journal of Hematology & Oncology Insulin-like growth factor Cancer Receptor tyrosine kinase Tumorigenesis Drug resistance |
| title | Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy |
| title_full | Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy |
| title_fullStr | Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy |
| title_full_unstemmed | Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy |
| title_short | Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy |
| title_sort | insulin like growth factor receptor signaling in tumorigenesis and drug resistance a challenge for cancer therapy |
| topic | Insulin-like growth factor Cancer Receptor tyrosine kinase Tumorigenesis Drug resistance |
| url | http://link.springer.com/article/10.1186/s13045-020-00904-3 |
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