Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy

Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy

Abstract Insulin-like growth factors (IGFs) play important roles in mammalian growth, development, aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and tumor progression, thus providing the rationale for targeting IGF axis in cancer. However, clinical trials of the t...

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Bibliographic Details
Main Authors: Hui Hua, Qingbin Kong, Jie Yin, Jin Zhang, Yangfu Jiang
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Hematology & Oncology
Subjects:
Insulin-like growth factor
Cancer
Receptor tyrosine kinase
Tumorigenesis
Drug resistance
Online Access:http://link.springer.com/article/10.1186/s13045-020-00904-3

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