Irinotecan drug eluting beads used as a treatment of advanced intra hepatic cholangiocarcinoma
<p>This report describes a 74-year-old male with unresectable intrahepatic cholangiocarcinoma (ICC). However surgical procedure is the only curative treatment, it often seems to be ineffective because of the aggressive behaviour of the disease. The role of systemic chemotherapy in the...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
EduRad Publishing
2008-10-01
|
| Series: | Journal of Radiology Case Reports |
| Subjects: | |
| Online Access: | http://www.radiologycases.com/index.php/radiologycases/article/view/48 |
| _version_ | 1819136857887211520 |
|---|---|
| author | Jean Amede Roch John Palma-Gutierrez Marie Georges Lapalus Carole Paillet Frank Pilleul |
| author_facet | Jean Amede Roch John Palma-Gutierrez Marie Georges Lapalus Carole Paillet Frank Pilleul |
| author_sort | Jean Amede Roch |
| collection | DOAJ |
| description | <p>This report describes a 74-year-old male with unresectable intrahepatic cholangiocarcinoma (ICC). However surgical procedure is the only curative treatment, it often seems to be ineffective because of the aggressive behaviour of the disease. The role of systemic chemotherapy in the ICC is undefined with a median survival between 6.43 to 12.17 months obtained by using the combination chemotherapy of gemcitabine with cisplatin. In the present case, we performed a targeted treatment using drug eluting beads (DEB) with irinotecan (IRI) administered as transarterial-chemoembolization (TACE). After one session, the tumour vascularity decreased significantly at the one month evaluation on computed tomography (CT) scan of the liver. This case report suggested that minimally invasive transcatheter DEB embolization could be a promising, safe and effective treatment for selective patients with unresectable ICC.</p> |
| first_indexed | 2024-12-22T10:41:39Z |
| format | Article |
| id | doaj.art-06b4aca0907d479f86bc86f6ffa9dabc |
| institution | Directory Open Access Journal |
| issn | 1943-0922 |
| language | English |
| last_indexed | 2024-12-22T10:41:39Z |
| publishDate | 2008-10-01 |
| publisher | EduRad Publishing |
| record_format | Article |
| series | Journal of Radiology Case Reports |
| spelling | doaj.art-06b4aca0907d479f86bc86f6ffa9dabc2022-12-21T18:29:00ZengEduRad PublishingJournal of Radiology Case Reports1943-09222008-10-0124242710.3941/jrcr.v2i4.48Irinotecan drug eluting beads used as a treatment of advanced intra hepatic cholangiocarcinomaJean Amede RochJohn Palma-GutierrezMarie Georges LapalusCarole PailletFrank Pilleul<p>This report describes a 74-year-old male with unresectable intrahepatic cholangiocarcinoma (ICC). However surgical procedure is the only curative treatment, it often seems to be ineffective because of the aggressive behaviour of the disease. The role of systemic chemotherapy in the ICC is undefined with a median survival between 6.43 to 12.17 months obtained by using the combination chemotherapy of gemcitabine with cisplatin. In the present case, we performed a targeted treatment using drug eluting beads (DEB) with irinotecan (IRI) administered as transarterial-chemoembolization (TACE). After one session, the tumour vascularity decreased significantly at the one month evaluation on computed tomography (CT) scan of the liver. This case report suggested that minimally invasive transcatheter DEB embolization could be a promising, safe and effective treatment for selective patients with unresectable ICC.</p>http://www.radiologycases.com/index.php/radiologycases/article/view/48Intrahepatic CholangiocarcinomaIrinotecanDrug Eluting BeadsTransarterial-chemoembolization |
| spellingShingle | Jean Amede Roch John Palma-Gutierrez Marie Georges Lapalus Carole Paillet Frank Pilleul Irinotecan drug eluting beads used as a treatment of advanced intra hepatic cholangiocarcinoma Journal of Radiology Case Reports Intrahepatic Cholangiocarcinoma Irinotecan Drug Eluting Beads Transarterial-chemoembolization |
| title | Irinotecan drug eluting beads used as a treatment of advanced intra hepatic cholangiocarcinoma |
| title_full | Irinotecan drug eluting beads used as a treatment of advanced intra hepatic cholangiocarcinoma |
| title_fullStr | Irinotecan drug eluting beads used as a treatment of advanced intra hepatic cholangiocarcinoma |
| title_full_unstemmed | Irinotecan drug eluting beads used as a treatment of advanced intra hepatic cholangiocarcinoma |
| title_short | Irinotecan drug eluting beads used as a treatment of advanced intra hepatic cholangiocarcinoma |
| title_sort | irinotecan drug eluting beads used as a treatment of advanced intra hepatic cholangiocarcinoma |
| topic | Intrahepatic Cholangiocarcinoma Irinotecan Drug Eluting Beads Transarterial-chemoembolization |
| url | http://www.radiologycases.com/index.php/radiologycases/article/view/48 |
| work_keys_str_mv | AT jeanamederoch irinotecandrugelutingbeadsusedasatreatmentofadvancedintrahepaticcholangiocarcinoma AT johnpalmagutierrez irinotecandrugelutingbeadsusedasatreatmentofadvancedintrahepaticcholangiocarcinoma AT mariegeorgeslapalus irinotecandrugelutingbeadsusedasatreatmentofadvancedintrahepaticcholangiocarcinoma AT carolepaillet irinotecandrugelutingbeadsusedasatreatmentofadvancedintrahepaticcholangiocarcinoma AT frankpilleul irinotecandrugelutingbeadsusedasatreatmentofadvancedintrahepaticcholangiocarcinoma |