In utero Exposure to Maternal Chronic Inflammation Transfers a Pro-Inflammatory Profile to Generation F2 via Sex-Specific Mechanisms

In utero Exposure to Maternal Chronic Inflammation Transfers a Pro-Inflammatory Profile to Generation F2 via Sex-Specific Mechanisms

Generational transfer of maladaptations in offspring have been reported to persist for multiple generations in conditions of chronic inflammation, metabolic and psychological stress. Thus, the current study aimed to expand our understanding of the nature, potential sex specificity, and transgenerati...

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Bibliographic Details
Main Authors: Rozanne Charlene McChary Adams, Carine Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
infection
cytokine
glucocorticoid receptor
gender
transgenerational inheritance
periconception systemic inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00048/full

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