Autologous platelet-rich plasma in the treatment of refractory corneal ulcers: A case report
Purpose: To evaluate the efficacy of a low-cost preparation of platelet-rich plasma (PRP) eye drops in the treatment of persistent non-infectious corneal ulcer. Observations: A 67-year-old female presented to our clinic with a wide corneal ulcer and severe paracentral corneal thinning refractory to...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-12-01
|
| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993618300641 |
| _version_ | 1828947367429144576 |
|---|---|
| author | Miguel Rechichi, MD PhD Marco Ferrise, MD Febo Francesco Romano, MD Luca Gallelli, MD Vincenzo Toschi Andrea Dominijanni Alessandro Meduri, MD |
| author_facet | Miguel Rechichi, MD PhD Marco Ferrise, MD Febo Francesco Romano, MD Luca Gallelli, MD Vincenzo Toschi Andrea Dominijanni Alessandro Meduri, MD |
| author_sort | Miguel Rechichi, MD PhD |
| collection | DOAJ |
| description | Purpose: To evaluate the efficacy of a low-cost preparation of platelet-rich plasma (PRP) eye drops in the treatment of persistent non-infectious corneal ulcer. Observations: A 67-year-old female presented to our clinic with a wide corneal ulcer and severe paracentral corneal thinning refractory to medical therapy with antibiotics, lubricant and contact lens bandage. The patient received a novel preparation of PRP solution. After 15 days of therapy, we observed complete resolution of the corneal ulcer with regrowth of the epithelium and a reduction in corneal opacity. Conclusion and importance: Although the low-cost PRP preparation gives a lower platelet concentration than standard procedures, our work shows this preparation to be effective in the treatment of refractory non-infectious corneal ulcer. |
| first_indexed | 2024-12-14T05:27:18Z |
| format | Article |
| id | doaj.art-06b7dd2e5c3e4a48a03fe9ea66aa2668 |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2024-12-14T05:27:18Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-06b7dd2e5c3e4a48a03fe9ea66aa26682022-12-21T23:15:27ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362020-12-0120100838Autologous platelet-rich plasma in the treatment of refractory corneal ulcers: A case reportMiguel Rechichi, MD PhD0Marco Ferrise, MD Febo1Francesco Romano, MD2Luca Gallelli, MD3Vincenzo Toschi4Andrea Dominijanni5Alessandro Meduri, MD6Centro Polispecialistico Mediterraneo, Sellia Marina, Catanzaro, Italy; Corresponding author.Biomorf, University of Messina, Messina, 98100, ItalyDepartment of General Medicine, ASP, Catanzaro, ItalyClinical Pharmacology and Pharmacovigilance Operative Unit, Mater Domini Hospital, Catanzaro, ItalyDivision of Haematology and Blood Transfusion and Thrombosis Centre, AO Ospedale San Carlo Borromeo, Milan, ItalyAzienda Ospedaiera Pugliese Ciaccio, Catanzaro, ItalyCentro Polispecialistico Mediterraneo, Sellia Marina, Catanzaro, ItalyPurpose: To evaluate the efficacy of a low-cost preparation of platelet-rich plasma (PRP) eye drops in the treatment of persistent non-infectious corneal ulcer. Observations: A 67-year-old female presented to our clinic with a wide corneal ulcer and severe paracentral corneal thinning refractory to medical therapy with antibiotics, lubricant and contact lens bandage. The patient received a novel preparation of PRP solution. After 15 days of therapy, we observed complete resolution of the corneal ulcer with regrowth of the epithelium and a reduction in corneal opacity. Conclusion and importance: Although the low-cost PRP preparation gives a lower platelet concentration than standard procedures, our work shows this preparation to be effective in the treatment of refractory non-infectious corneal ulcer.http://www.sciencedirect.com/science/article/pii/S2451993618300641Corneal ulcerPlatelet-rich plasmaRefractory ulcer |
| spellingShingle | Miguel Rechichi, MD PhD Marco Ferrise, MD Febo Francesco Romano, MD Luca Gallelli, MD Vincenzo Toschi Andrea Dominijanni Alessandro Meduri, MD Autologous platelet-rich plasma in the treatment of refractory corneal ulcers: A case report American Journal of Ophthalmology Case Reports Corneal ulcer Platelet-rich plasma Refractory ulcer |
| title | Autologous platelet-rich plasma in the treatment of refractory corneal ulcers: A case report |
| title_full | Autologous platelet-rich plasma in the treatment of refractory corneal ulcers: A case report |
| title_fullStr | Autologous platelet-rich plasma in the treatment of refractory corneal ulcers: A case report |
| title_full_unstemmed | Autologous platelet-rich plasma in the treatment of refractory corneal ulcers: A case report |
| title_short | Autologous platelet-rich plasma in the treatment of refractory corneal ulcers: A case report |
| title_sort | autologous platelet rich plasma in the treatment of refractory corneal ulcers a case report |
| topic | Corneal ulcer Platelet-rich plasma Refractory ulcer |
| url | http://www.sciencedirect.com/science/article/pii/S2451993618300641 |
| work_keys_str_mv | AT miguelrechichimdphd autologousplateletrichplasmainthetreatmentofrefractorycornealulcersacasereport AT marcoferrisemdfebo autologousplateletrichplasmainthetreatmentofrefractorycornealulcersacasereport AT francescoromanomd autologousplateletrichplasmainthetreatmentofrefractorycornealulcersacasereport AT lucagallellimd autologousplateletrichplasmainthetreatmentofrefractorycornealulcersacasereport AT vincenzotoschi autologousplateletrichplasmainthetreatmentofrefractorycornealulcersacasereport AT andreadominijanni autologousplateletrichplasmainthetreatmentofrefractorycornealulcersacasereport AT alessandromedurimd autologousplateletrichplasmainthetreatmentofrefractorycornealulcersacasereport |