Assessment of the analgesic effect of Alpha-lipoic acid by three acute pain models
Alpha-lipoic acids are Known as a good analgesic in neuropathic pain, especially in diabetic patients. This research aimed to assess the analgesic activity of ALA by three acute pain models using broiler chicks. We used electrical stimulation, hot water test, and formalin test to elicit acute pain....
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Arabic |
| Published: |
University of Mosul, College of Veterinary Medicine
2022-06-01
|
| Series: | Iraqi Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | https://vetmedmosul.com/article_173315_233d292b0bc4810e95586d7811b4cf47.pdf |
| _version_ | 1818549334292037632 |
|---|---|
| author | Marwa R. Rehab Ahmed S. Naser |
| author_facet | Marwa R. Rehab Ahmed S. Naser |
| author_sort | Marwa R. Rehab |
| collection | DOAJ |
| description | Alpha-lipoic acids are Known as a good analgesic in neuropathic pain, especially in diabetic patients. This research aimed to assess the analgesic activity of ALA by three acute pain models using broiler chicks. We used electrical stimulation, hot water test, and formalin test to elicit acute pain. The up and down method was used to calculate the median effect of the analgesic dose. The ED50 of ALA was 45.18 and 74.56 mg/kg intraperitoneally by electrical stimulation and hot water test, respectively. We demonstrated that the peak of analgesic effect was after one hour by using different doses and different times. ALA at 0, 75, 150, 300 mg/kg intraperitoneally produces a dose-dependent analgesic effect by formalin test. In conclusion: ALA induced analgesic activity, probably by closing voltage-gated calcium and or voltage-gated sodium channels. These outcomes show that therapeutic doses of ALA can affect pain and may mask or reduce nociception induced by acute pain models. |
| first_indexed | 2024-12-12T08:32:00Z |
| format | Article |
| id | doaj.art-06b8194ef1b74f7a898d86fbceef380c |
| institution | Directory Open Access Journal |
| issn | 1607-3894 2071-1255 |
| language | Arabic |
| last_indexed | 2024-12-12T08:32:00Z |
| publishDate | 2022-06-01 |
| publisher | University of Mosul, College of Veterinary Medicine |
| record_format | Article |
| series | Iraqi Journal of Veterinary Sciences |
| spelling | doaj.art-06b8194ef1b74f7a898d86fbceef380c2022-12-22T00:31:03ZaraUniversity of Mosul, College of Veterinary MedicineIraqi Journal of Veterinary Sciences1607-38942071-12552022-06-0136380380710.33899/ijvs.2022.132184.2062173315Assessment of the analgesic effect of Alpha-lipoic acid by three acute pain modelsMarwa R. Rehab0Ahmed S. Naser1Department of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, IraqDepartment of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, IraqAlpha-lipoic acids are Known as a good analgesic in neuropathic pain, especially in diabetic patients. This research aimed to assess the analgesic activity of ALA by three acute pain models using broiler chicks. We used electrical stimulation, hot water test, and formalin test to elicit acute pain. The up and down method was used to calculate the median effect of the analgesic dose. The ED50 of ALA was 45.18 and 74.56 mg/kg intraperitoneally by electrical stimulation and hot water test, respectively. We demonstrated that the peak of analgesic effect was after one hour by using different doses and different times. ALA at 0, 75, 150, 300 mg/kg intraperitoneally produces a dose-dependent analgesic effect by formalin test. In conclusion: ALA induced analgesic activity, probably by closing voltage-gated calcium and or voltage-gated sodium channels. These outcomes show that therapeutic doses of ALA can affect pain and may mask or reduce nociception induced by acute pain models.https://vetmedmosul.com/article_173315_233d292b0bc4810e95586d7811b4cf47.pdfalpha lipoic acidanalgesiaelectrical stimulationhot water testformalin test |
| spellingShingle | Marwa R. Rehab Ahmed S. Naser Assessment of the analgesic effect of Alpha-lipoic acid by three acute pain models Iraqi Journal of Veterinary Sciences alpha lipoic acid analgesia electrical stimulation hot water test formalin test |
| title | Assessment of the analgesic effect of Alpha-lipoic acid by three acute pain models |
| title_full | Assessment of the analgesic effect of Alpha-lipoic acid by three acute pain models |
| title_fullStr | Assessment of the analgesic effect of Alpha-lipoic acid by three acute pain models |
| title_full_unstemmed | Assessment of the analgesic effect of Alpha-lipoic acid by three acute pain models |
| title_short | Assessment of the analgesic effect of Alpha-lipoic acid by three acute pain models |
| title_sort | assessment of the analgesic effect of alpha lipoic acid by three acute pain models |
| topic | alpha lipoic acid analgesia electrical stimulation hot water test formalin test |
| url | https://vetmedmosul.com/article_173315_233d292b0bc4810e95586d7811b4cf47.pdf |
| work_keys_str_mv | AT marwarrehab assessmentoftheanalgesiceffectofalphalipoicacidbythreeacutepainmodels AT ahmedsnaser assessmentoftheanalgesiceffectofalphalipoicacidbythreeacutepainmodels |