NEURO-VASCULAR CONFLICT AS CAUSATIVE FACTOR IN IDI-OPATHIC TRIGEMINAL NEURALGIA
<h3>Introduction</h3> <p class="matn">Trigeminal neuralgia is one of the most unbearable pain syndromes in one or more branches of trigeminal nerve. The basic pathology is still poorly understood <sup>1</sup><sub>.</sub> Two divergent view points,...
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| Format: | Article |
| Language: | English |
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Vesnu Publications
2010-12-01
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| Series: | ARYA Atherosclerosis |
| Online Access: | http://arya.mui.ac.ir/index.php/arya/article/view/125 |
| _version_ | 1811225103453650944 |
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| author | Mumtaz Ali Hamzullah Khan |
| author_facet | Mumtaz Ali Hamzullah Khan |
| author_sort | Mumtaz Ali |
| collection | DOAJ |
| description | <h3>Introduction</h3> <p class="matn">Trigeminal neuralgia is one of the most unbearable pain syndromes in one or more branches of trigeminal nerve. The basic pathology is still poorly understood <sup>1</sup><sub>.</sub> Two divergent view points, central versus peripheral have been presented to explain the possible mechanism <sup>2</sup>. In spite of numerous favorable reports, the neurovascular conflict theory remains contra-vertical <sup>3</sup>. Nevertheless, whether or not, neurovascular compression is accessory or predominant in the mechanism of trigeminal neuralgia is not yet determined. Although neurovascular compression and global atrophy of the root, a focal arachnoid thickening and angulated root on crossing over the petrous ridge have been observed. Yet, neurovascular conflict has made responsible as the main cause of this neuralgia <sup>4</sup>. This lead to focal demylination of the nerve due to its pulsatile compression. Demylination result in short circuiting of neuronal flow and hence trigeminal neuralgia <sup>5</sup>.</p> <p class="matn"> Present study was therefore designed as to appreciate neurovascular conflict as causative agent in idiopathic trigeminal neuralgia.</p> <h3>Material and Methods</h3> <p class="matn">This prospective observational study was conducted in department of Neurosurgery Government Lady Reading Hospital Peshawar where microvascular decompression is performed as a primary procedure of choice for patients with trigeminal neuralgia. The duration of this study was from May 2003 – to June 2007. Total number of patients operated was 86. Drug resistant cases of trigeminal neuralgia that were <br /> <br /></p> <p class="matn"> </p> <p class="matn">willing for operation was selected and proper clinical record was documented. MRI was done in all patients to exclude secondary causes of trigeminal Neuralgia. Under general Anesthesia in lateral position, small 2.5x2.5cm retro-mastoid craniotomy was performed. All these cases were operated by one surgeon with a team of associate’s doctors. Microscopic per-operative anatomical findings were recorded. Any possible per-operative complications were also documented.</p> |
| first_indexed | 2024-04-12T09:00:09Z |
| format | Article |
| id | doaj.art-06b8462ba35d4f309e0451d6e70481dd |
| institution | Directory Open Access Journal |
| issn | 1735-3955 2251-6638 |
| language | English |
| last_indexed | 2024-04-12T09:00:09Z |
| publishDate | 2010-12-01 |
| publisher | Vesnu Publications |
| record_format | Article |
| series | ARYA Atherosclerosis |
| spelling | doaj.art-06b8462ba35d4f309e0451d6e70481dd2022-12-22T03:39:15ZengVesnu PublicationsARYA Atherosclerosis1735-39552251-66382010-12-0133101NEURO-VASCULAR CONFLICT AS CAUSATIVE FACTOR IN IDI-OPATHIC TRIGEMINAL NEURALGIAMumtaz Ali0Hamzullah Khan1Assistant Professor, Department of Neurosurgery, Postgraduate Medical Institute, Lady Reading Hospital, Peshawar, Pakistan.MBBS, Department of Neurosurgery, Postgraduate Medical Institute, Lady Reading Hospital, Peshawar, Pakistan.<h3>Introduction</h3> <p class="matn">Trigeminal neuralgia is one of the most unbearable pain syndromes in one or more branches of trigeminal nerve. The basic pathology is still poorly understood <sup>1</sup><sub>.</sub> Two divergent view points, central versus peripheral have been presented to explain the possible mechanism <sup>2</sup>. In spite of numerous favorable reports, the neurovascular conflict theory remains contra-vertical <sup>3</sup>. Nevertheless, whether or not, neurovascular compression is accessory or predominant in the mechanism of trigeminal neuralgia is not yet determined. Although neurovascular compression and global atrophy of the root, a focal arachnoid thickening and angulated root on crossing over the petrous ridge have been observed. Yet, neurovascular conflict has made responsible as the main cause of this neuralgia <sup>4</sup>. This lead to focal demylination of the nerve due to its pulsatile compression. Demylination result in short circuiting of neuronal flow and hence trigeminal neuralgia <sup>5</sup>.</p> <p class="matn"> Present study was therefore designed as to appreciate neurovascular conflict as causative agent in idiopathic trigeminal neuralgia.</p> <h3>Material and Methods</h3> <p class="matn">This prospective observational study was conducted in department of Neurosurgery Government Lady Reading Hospital Peshawar where microvascular decompression is performed as a primary procedure of choice for patients with trigeminal neuralgia. The duration of this study was from May 2003 – to June 2007. Total number of patients operated was 86. Drug resistant cases of trigeminal neuralgia that were <br /> <br /></p> <p class="matn"> </p> <p class="matn">willing for operation was selected and proper clinical record was documented. MRI was done in all patients to exclude secondary causes of trigeminal Neuralgia. Under general Anesthesia in lateral position, small 2.5x2.5cm retro-mastoid craniotomy was performed. All these cases were operated by one surgeon with a team of associate’s doctors. Microscopic per-operative anatomical findings were recorded. Any possible per-operative complications were also documented.</p>http://arya.mui.ac.ir/index.php/arya/article/view/125 |
| spellingShingle | Mumtaz Ali Hamzullah Khan NEURO-VASCULAR CONFLICT AS CAUSATIVE FACTOR IN IDI-OPATHIC TRIGEMINAL NEURALGIA ARYA Atherosclerosis |
| title | NEURO-VASCULAR CONFLICT AS CAUSATIVE FACTOR IN IDI-OPATHIC TRIGEMINAL NEURALGIA |
| title_full | NEURO-VASCULAR CONFLICT AS CAUSATIVE FACTOR IN IDI-OPATHIC TRIGEMINAL NEURALGIA |
| title_fullStr | NEURO-VASCULAR CONFLICT AS CAUSATIVE FACTOR IN IDI-OPATHIC TRIGEMINAL NEURALGIA |
| title_full_unstemmed | NEURO-VASCULAR CONFLICT AS CAUSATIVE FACTOR IN IDI-OPATHIC TRIGEMINAL NEURALGIA |
| title_short | NEURO-VASCULAR CONFLICT AS CAUSATIVE FACTOR IN IDI-OPATHIC TRIGEMINAL NEURALGIA |
| title_sort | neuro vascular conflict as causative factor in idi opathic trigeminal neuralgia |
| url | http://arya.mui.ac.ir/index.php/arya/article/view/125 |
| work_keys_str_mv | AT mumtazali neurovascularconflictascausativefactorinidiopathictrigeminalneuralgia AT hamzullahkhan neurovascularconflictascausativefactorinidiopathictrigeminalneuralgia |