Chronic jet lag-like conditions dysregulate molecular profiles of neurological disorders in nucleus accumbens and prefrontal cortex
BackgroundPatients with neurological disorders often display altered circadian rhythms. The disrupted circadian rhythms through chronic jetlag or shiftwork are thought to increase the risk and severity of human disease including, cancer, psychiatric, and related brain diseases.ResultsIn this study,...
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Neuroinformatics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fninf.2022.1031448/full |
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| author | Rabeea Siddique Rabeea Siddique Faryal Mehwish Awan Ghulam Nabi Suliman Khan Suliman Khan Suliman Khan Mengzhou Xue Mengzhou Xue |
| author_facet | Rabeea Siddique Rabeea Siddique Faryal Mehwish Awan Ghulam Nabi Suliman Khan Suliman Khan Suliman Khan Mengzhou Xue Mengzhou Xue |
| author_sort | Rabeea Siddique |
| collection | DOAJ |
| description | BackgroundPatients with neurological disorders often display altered circadian rhythms. The disrupted circadian rhythms through chronic jetlag or shiftwork are thought to increase the risk and severity of human disease including, cancer, psychiatric, and related brain diseases.ResultsIn this study, we investigated the impact of shiftwork or chronic jetlag (CJL) like conditions on mice’s brain. Transcriptome profiling based on RNA sequencing revealed that genes associated with serious neurological disorders were differentially expressed in the nucleus accumbens (NAc) and prefrontal cortex (PFC). According to the quantitative PCR (qPCR) analysis, several key regulatory genes associated with neurological disorders were significantly altered in the NAc, PFC, hypothalamus, hippocampus, and striatum. Serotonin levels and the expression levels of serotonin transporters and receptors were significantly altered in mice treated with CJL.ConclusionOverall, these results indicate that CJL may increase the risk of neurological disorders by disrupting the key regulatory genes, biological functions, serotonin, and corticosterone. These molecular linkages can further be studied to investigate the mechanism underlying CJL or shiftwork-mediated neurological disorders in order to develop treatment strategies. |
| first_indexed | 2024-04-12T01:27:01Z |
| format | Article |
| id | doaj.art-06b8777bfda44040847cc84c68f088f9 |
| institution | Directory Open Access Journal |
| issn | 1662-5196 |
| language | English |
| last_indexed | 2024-04-12T01:27:01Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroinformatics |
| spelling | doaj.art-06b8777bfda44040847cc84c68f088f92022-12-22T03:53:35ZengFrontiers Media S.A.Frontiers in Neuroinformatics1662-51962022-12-011610.3389/fninf.2022.10314481031448Chronic jet lag-like conditions dysregulate molecular profiles of neurological disorders in nucleus accumbens and prefrontal cortexRabeea Siddique0Rabeea Siddique1Faryal Mehwish Awan2Ghulam Nabi3Suliman Khan4Suliman Khan5Suliman Khan6Mengzhou Xue7Mengzhou Xue8Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, Henan, ChinaDepartment of Medical Lab Technology, The University of Haripur, Haripur, PakistanInstitute of Nature Conservation, Polish Academy of Sciences, Kraków, PolandDepartment of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, Henan, ChinaDepartment of Medical Lab Technology, The University of Haripur, Haripur, PakistanDepartment of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, Henan, ChinaBackgroundPatients with neurological disorders often display altered circadian rhythms. The disrupted circadian rhythms through chronic jetlag or shiftwork are thought to increase the risk and severity of human disease including, cancer, psychiatric, and related brain diseases.ResultsIn this study, we investigated the impact of shiftwork or chronic jetlag (CJL) like conditions on mice’s brain. Transcriptome profiling based on RNA sequencing revealed that genes associated with serious neurological disorders were differentially expressed in the nucleus accumbens (NAc) and prefrontal cortex (PFC). According to the quantitative PCR (qPCR) analysis, several key regulatory genes associated with neurological disorders were significantly altered in the NAc, PFC, hypothalamus, hippocampus, and striatum. Serotonin levels and the expression levels of serotonin transporters and receptors were significantly altered in mice treated with CJL.ConclusionOverall, these results indicate that CJL may increase the risk of neurological disorders by disrupting the key regulatory genes, biological functions, serotonin, and corticosterone. These molecular linkages can further be studied to investigate the mechanism underlying CJL or shiftwork-mediated neurological disorders in order to develop treatment strategies.https://www.frontiersin.org/articles/10.3389/fninf.2022.1031448/fullcircadian rhythmschronic jetlag (shiftwork)neurological diseasesserotoninalternating light-dark cycles |
| spellingShingle | Rabeea Siddique Rabeea Siddique Faryal Mehwish Awan Ghulam Nabi Suliman Khan Suliman Khan Suliman Khan Mengzhou Xue Mengzhou Xue Chronic jet lag-like conditions dysregulate molecular profiles of neurological disorders in nucleus accumbens and prefrontal cortex Frontiers in Neuroinformatics circadian rhythms chronic jetlag (shiftwork) neurological diseases serotonin alternating light-dark cycles |
| title | Chronic jet lag-like conditions dysregulate molecular profiles of neurological disorders in nucleus accumbens and prefrontal cortex |
| title_full | Chronic jet lag-like conditions dysregulate molecular profiles of neurological disorders in nucleus accumbens and prefrontal cortex |
| title_fullStr | Chronic jet lag-like conditions dysregulate molecular profiles of neurological disorders in nucleus accumbens and prefrontal cortex |
| title_full_unstemmed | Chronic jet lag-like conditions dysregulate molecular profiles of neurological disorders in nucleus accumbens and prefrontal cortex |
| title_short | Chronic jet lag-like conditions dysregulate molecular profiles of neurological disorders in nucleus accumbens and prefrontal cortex |
| title_sort | chronic jet lag like conditions dysregulate molecular profiles of neurological disorders in nucleus accumbens and prefrontal cortex |
| topic | circadian rhythms chronic jetlag (shiftwork) neurological diseases serotonin alternating light-dark cycles |
| url | https://www.frontiersin.org/articles/10.3389/fninf.2022.1031448/full |
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