The Role of TRPC1 in Modulating Cancer Progression
Calcium ions (Ca<sup>2+</sup>) play an important role as second messengers in regulating a plethora of physiological and pathological processes, including the progression of cancer. Several selective and non-selective Ca<sup>2+</sup>-permeable ion channels are implicated in m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/2/388 |
| _version_ | 1827843133760602112 |
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| author | Osama M Elzamzamy Reinhold Penner Lori A Hazlehurst |
| author_facet | Osama M Elzamzamy Reinhold Penner Lori A Hazlehurst |
| author_sort | Osama M Elzamzamy |
| collection | DOAJ |
| description | Calcium ions (Ca<sup>2+</sup>) play an important role as second messengers in regulating a plethora of physiological and pathological processes, including the progression of cancer. Several selective and non-selective Ca<sup>2+</sup>-permeable ion channels are implicated in mediating Ca<sup>2+</sup> signaling in cancer cells. In this review, we are focusing on TRPC1, a member of the TRP protein superfamily and a potential modulator of store-operated Ca<sup>2+</sup> entry (SOCE) pathways. While TRPC1 is ubiquitously expressed in most tissues, its dysregulated activity may contribute to the hallmarks of various types of cancers, including breast cancer, pancreatic cancer, glioblastoma multiforme, lung cancer, hepatic cancer, multiple myeloma, and thyroid cancer. A range of pharmacological and genetic tools have been developed to address the functional role of TRPC1 in cancer. Interestingly, the unique role of TRPC1 has elevated this channel as a promising target for modulation both in terms of pharmacological inhibition leading to suppression of tumor growth and metastasis, as well as for agonistic strategies eliciting Ca<sup>2+</sup> overload and cell death in aggressive metastatic tumor cells. |
| first_indexed | 2024-03-12T08:20:22Z |
| format | Article |
| id | doaj.art-06b9ef40c72948cdbb3ae1e374ffc576 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T08:20:22Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-06b9ef40c72948cdbb3ae1e374ffc5762023-09-02T18:32:04ZengMDPI AGCells2073-44092020-02-019238810.3390/cells9020388cells9020388The Role of TRPC1 in Modulating Cancer ProgressionOsama M Elzamzamy0Reinhold Penner1Lori A Hazlehurst2Clinical and Translational Sciences Institute, School of Medicine, West Virginia University, Morgantown, WV 26506, USAThe Queen’s Medical Center and University of Hawaii, Honolulu, HI 96813, USAPharmaceutical Sciences, School of Pharmacy and WVU Cancer Institute, West Virginia University, Morganton, WV 26506, USACalcium ions (Ca<sup>2+</sup>) play an important role as second messengers in regulating a plethora of physiological and pathological processes, including the progression of cancer. Several selective and non-selective Ca<sup>2+</sup>-permeable ion channels are implicated in mediating Ca<sup>2+</sup> signaling in cancer cells. In this review, we are focusing on TRPC1, a member of the TRP protein superfamily and a potential modulator of store-operated Ca<sup>2+</sup> entry (SOCE) pathways. While TRPC1 is ubiquitously expressed in most tissues, its dysregulated activity may contribute to the hallmarks of various types of cancers, including breast cancer, pancreatic cancer, glioblastoma multiforme, lung cancer, hepatic cancer, multiple myeloma, and thyroid cancer. A range of pharmacological and genetic tools have been developed to address the functional role of TRPC1 in cancer. Interestingly, the unique role of TRPC1 has elevated this channel as a promising target for modulation both in terms of pharmacological inhibition leading to suppression of tumor growth and metastasis, as well as for agonistic strategies eliciting Ca<sup>2+</sup> overload and cell death in aggressive metastatic tumor cells.https://www.mdpi.com/2073-4409/9/2/388trpc1socecancer progressionemt |
| spellingShingle | Osama M Elzamzamy Reinhold Penner Lori A Hazlehurst The Role of TRPC1 in Modulating Cancer Progression Cells trpc1 soce cancer progression emt |
| title | The Role of TRPC1 in Modulating Cancer Progression |
| title_full | The Role of TRPC1 in Modulating Cancer Progression |
| title_fullStr | The Role of TRPC1 in Modulating Cancer Progression |
| title_full_unstemmed | The Role of TRPC1 in Modulating Cancer Progression |
| title_short | The Role of TRPC1 in Modulating Cancer Progression |
| title_sort | role of trpc1 in modulating cancer progression |
| topic | trpc1 soce cancer progression emt |
| url | https://www.mdpi.com/2073-4409/9/2/388 |
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