Virtual Clinical Trials Guided Design of an Age-Appropriate Formulation and Dosing Strategy of Nifedipine for Paediatric Use

Virtual Clinical Trials Guided Design of an Age-Appropriate Formulation and Dosing Strategy of Nifedipine for Paediatric Use

The rapid onset of action of nifedipine causes a precipitous reduction in blood pressure leading to adverse effects associated with reflex sympathetic nervous system (SNS) activation, including tachycardia and worsening myocardial and cerebrovascular ischemia. As a result, short acting nifedipine pr...

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Bibliographic Details
Main Authors: Dilawar Khan, Raj Badhan, Daniel J. Kirby, Simon Bryson, Maryam Shah, Afzal Rahman Mohammed
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
paediatrics
PBPK
pharmacokinetics
age-appropriate
mini-tablets
modified release
Online Access:https://www.mdpi.com/1999-4923/15/2/556

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