Thyroid Hormone and Heart Failure: Charting Known Pathways for Cardiac Repair/Regeneration
Heart failure affects more than 64 million people worldwide, having a serious impact on their survival and quality of life. Exploring its pathophysiology and molecular bases is an urgent need in order to develop new therapeutic approaches. Thyroid hormone signaling, evolutionarily conserved, control...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/3/975 |
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| author | Polyxeni Mantzouratou Eleftheria Malaxianaki Domenico Cerullo Angelo Michele Lavecchia Constantinos Pantos Christodoulos Xinaris Iordanis Mourouzis |
| author_facet | Polyxeni Mantzouratou Eleftheria Malaxianaki Domenico Cerullo Angelo Michele Lavecchia Constantinos Pantos Christodoulos Xinaris Iordanis Mourouzis |
| author_sort | Polyxeni Mantzouratou |
| collection | DOAJ |
| description | Heart failure affects more than 64 million people worldwide, having a serious impact on their survival and quality of life. Exploring its pathophysiology and molecular bases is an urgent need in order to develop new therapeutic approaches. Thyroid hormone signaling, evolutionarily conserved, controls fundamental biological processes and has a crucial role in development and metabolism. Its active form is L-triiodothyronine, which not only regulates important gene expression by binding to its nuclear receptors, but also has nongenomic actions, controlling crucial intracellular signalings. Stressful stimuli, such as acute myocardial infarction, lead to changes in thyroid hormone signaling, and especially in the relation of the thyroid hormone and its nuclear receptor, which are associated with the reactivation of fetal development programmes, with structural remodeling and phenotypical changes in the cardiomyocytes. The recapitulation of fetal-like features of the signaling may be partially an incomplete effort of the myocardium to recapitulate its developmental program and enable cardiomyocytes to proliferate and finally to regenerate. In this review, we will discuss the experimental and clinical evidence about the role of the thyroid hormone in the recovery of the myocardium in the setting of heart failure with reduced and preserved ejection fraction and its future therapeutic implications. |
| first_indexed | 2024-03-11T06:53:10Z |
| format | Article |
| id | doaj.art-06baaaa5c2904732a004f31cffb25628 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T06:53:10Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-06baaaa5c2904732a004f31cffb256282023-11-17T09:48:21ZengMDPI AGBiomedicines2227-90592023-03-0111397510.3390/biomedicines11030975Thyroid Hormone and Heart Failure: Charting Known Pathways for Cardiac Repair/RegenerationPolyxeni Mantzouratou0Eleftheria Malaxianaki1Domenico Cerullo2Angelo Michele Lavecchia3Constantinos Pantos4Christodoulos Xinaris5Iordanis Mourouzis6Department of Pharmacology, University of Athens, 11527 Athens, GreeceDepartment of Pharmacology, University of Athens, 11527 Athens, GreeceCentro Anna Maria Astori, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 24126 Bergamo, ItalyCentro Anna Maria Astori, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 24126 Bergamo, ItalyDepartment of Pharmacology, University of Athens, 11527 Athens, GreeceCentro Anna Maria Astori, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 24126 Bergamo, ItalyDepartment of Pharmacology, University of Athens, 11527 Athens, GreeceHeart failure affects more than 64 million people worldwide, having a serious impact on their survival and quality of life. Exploring its pathophysiology and molecular bases is an urgent need in order to develop new therapeutic approaches. Thyroid hormone signaling, evolutionarily conserved, controls fundamental biological processes and has a crucial role in development and metabolism. Its active form is L-triiodothyronine, which not only regulates important gene expression by binding to its nuclear receptors, but also has nongenomic actions, controlling crucial intracellular signalings. Stressful stimuli, such as acute myocardial infarction, lead to changes in thyroid hormone signaling, and especially in the relation of the thyroid hormone and its nuclear receptor, which are associated with the reactivation of fetal development programmes, with structural remodeling and phenotypical changes in the cardiomyocytes. The recapitulation of fetal-like features of the signaling may be partially an incomplete effort of the myocardium to recapitulate its developmental program and enable cardiomyocytes to proliferate and finally to regenerate. In this review, we will discuss the experimental and clinical evidence about the role of the thyroid hormone in the recovery of the myocardium in the setting of heart failure with reduced and preserved ejection fraction and its future therapeutic implications.https://www.mdpi.com/2227-9059/11/3/975thyroid hormonethyroid receptorslow T3 syndromeheart failurecoronary diseasecardiac remodeling |
| spellingShingle | Polyxeni Mantzouratou Eleftheria Malaxianaki Domenico Cerullo Angelo Michele Lavecchia Constantinos Pantos Christodoulos Xinaris Iordanis Mourouzis Thyroid Hormone and Heart Failure: Charting Known Pathways for Cardiac Repair/Regeneration Biomedicines thyroid hormone thyroid receptors low T3 syndrome heart failure coronary disease cardiac remodeling |
| title | Thyroid Hormone and Heart Failure: Charting Known Pathways for Cardiac Repair/Regeneration |
| title_full | Thyroid Hormone and Heart Failure: Charting Known Pathways for Cardiac Repair/Regeneration |
| title_fullStr | Thyroid Hormone and Heart Failure: Charting Known Pathways for Cardiac Repair/Regeneration |
| title_full_unstemmed | Thyroid Hormone and Heart Failure: Charting Known Pathways for Cardiac Repair/Regeneration |
| title_short | Thyroid Hormone and Heart Failure: Charting Known Pathways for Cardiac Repair/Regeneration |
| title_sort | thyroid hormone and heart failure charting known pathways for cardiac repair regeneration |
| topic | thyroid hormone thyroid receptors low T3 syndrome heart failure coronary disease cardiac remodeling |
| url | https://www.mdpi.com/2227-9059/11/3/975 |
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