Extracellular vesicles as novel drug delivery systems to target cancer and other diseases: Recent advancements and future perspectives [version 1; peer review: 2 approved]
Extracellular vesicles (EVs) are lipid-bound vesicles produced into the extracellular space by cells. Apoptotic bodies (ApoBD), microvesicles (MVs), and exosomes are examples of EVs, which act as essential regulators in cell-cell communication in both normal and diseased conditions. Natural cargo mo...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2023-03-01
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| Series: | F1000Research |
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| Online Access: | https://f1000research.com/articles/12-329/v1 |
| _version_ | 1797653999098265600 |
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| author | Shankar Bakkannavar Krishna Sharan Divya Ramesh Vinutha R Bhat |
| author_facet | Shankar Bakkannavar Krishna Sharan Divya Ramesh Vinutha R Bhat |
| author_sort | Shankar Bakkannavar |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) are lipid-bound vesicles produced into the extracellular space by cells. Apoptotic bodies (ApoBD), microvesicles (MVs), and exosomes are examples of EVs, which act as essential regulators in cell-cell communication in both normal and diseased conditions. Natural cargo molecules such as miRNA, messenger RNA, and proteins are carried by EVs and transferred to nearby cells or distant cells through the process of circulation. Different signalling cascades are then influenced by these functionally active molecules. The information to be delivered to the target cells depends on the substances within the EVs that also includes synthesis method. EVs have attracted interest as potential delivery vehicles for therapies due to their features such as improved circulation stability, biocompatibility, reduced immunogenicity, and toxicity. Therefore, EVs are being regarded as potent carriers of therapeutics that can be used as a therapeutic agent for diseases like cancer. This review focuses on the exosome-mediated drug delivery to cancer cells and the advantages and challenges of using exosomes as a carrier molecule. |
| first_indexed | 2024-03-11T16:52:02Z |
| format | Article |
| id | doaj.art-06bfefb0c591402a9897ecb98dd79be6 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-03-11T16:52:02Z |
| publishDate | 2023-03-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-06bfefb0c591402a9897ecb98dd79be62023-10-21T00:00:02ZengF1000 Research LtdF1000Research2046-14022023-03-0112145092Extracellular vesicles as novel drug delivery systems to target cancer and other diseases: Recent advancements and future perspectives [version 1; peer review: 2 approved]Shankar Bakkannavar0https://orcid.org/0000-0001-6599-7014Krishna Sharan1Divya Ramesh2Vinutha R Bhat3Forensic Medicine and Toxicology, Katsurba Medical College, Manipal, Manipal Academy of Higher Education, MAHE, Manipal, Karnataka, 576104, IndiaRadiotherapy Oncology, Katsurba Medical College, Manipal, Manipal Academy of Higher Education, MAHE, Manipal, Karnataka, 576104, IndiaForensic Medicine and Toxicology, Katsurba Medical College, Manipal, Manipal Academy of Higher Education, MAHE, Manipal, Karnataka, 576104, IndiaBiochemistry, Katsurba Medical College, Manipal, Manipal Academy of Higher Education, MAHE, Manipal, Karnataka, 576104, IndiaExtracellular vesicles (EVs) are lipid-bound vesicles produced into the extracellular space by cells. Apoptotic bodies (ApoBD), microvesicles (MVs), and exosomes are examples of EVs, which act as essential regulators in cell-cell communication in both normal and diseased conditions. Natural cargo molecules such as miRNA, messenger RNA, and proteins are carried by EVs and transferred to nearby cells or distant cells through the process of circulation. Different signalling cascades are then influenced by these functionally active molecules. The information to be delivered to the target cells depends on the substances within the EVs that also includes synthesis method. EVs have attracted interest as potential delivery vehicles for therapies due to their features such as improved circulation stability, biocompatibility, reduced immunogenicity, and toxicity. Therefore, EVs are being regarded as potent carriers of therapeutics that can be used as a therapeutic agent for diseases like cancer. This review focuses on the exosome-mediated drug delivery to cancer cells and the advantages and challenges of using exosomes as a carrier molecule.https://f1000research.com/articles/12-329/v1EXTRACELLULAR VESICLES; Exosomes; Signalling cascade; Biocompatibility; Biogenesis;Cancereng |
| spellingShingle | Shankar Bakkannavar Krishna Sharan Divya Ramesh Vinutha R Bhat Extracellular vesicles as novel drug delivery systems to target cancer and other diseases: Recent advancements and future perspectives [version 1; peer review: 2 approved] F1000Research EXTRACELLULAR VESICLES ; Exosomes; Signalling cascade; Biocompatibility; Biogenesis;Cancer eng |
| title | Extracellular vesicles as novel drug delivery systems to target cancer and other diseases: Recent advancements and future perspectives [version 1; peer review: 2 approved] |
| title_full | Extracellular vesicles as novel drug delivery systems to target cancer and other diseases: Recent advancements and future perspectives [version 1; peer review: 2 approved] |
| title_fullStr | Extracellular vesicles as novel drug delivery systems to target cancer and other diseases: Recent advancements and future perspectives [version 1; peer review: 2 approved] |
| title_full_unstemmed | Extracellular vesicles as novel drug delivery systems to target cancer and other diseases: Recent advancements and future perspectives [version 1; peer review: 2 approved] |
| title_short | Extracellular vesicles as novel drug delivery systems to target cancer and other diseases: Recent advancements and future perspectives [version 1; peer review: 2 approved] |
| title_sort | extracellular vesicles as novel drug delivery systems to target cancer and other diseases recent advancements and future perspectives version 1 peer review 2 approved |
| topic | EXTRACELLULAR VESICLES ; Exosomes; Signalling cascade; Biocompatibility; Biogenesis;Cancer eng |
| url | https://f1000research.com/articles/12-329/v1 |
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