Personalized Neuromodulation: A Novel Strategy for Improving Tinnitus Treatment
This study evaluated the efficacy of personalized neuromodulation, where treatment modalities are chosen based on the patient’s responses in a pilot trial. A total of 71 patients with tinnitus were divided into two groups: a personalized group and a randomized neuromodulation group. In the personali...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/22/6987 |
| _version_ | 1797458820647092224 |
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| author | Seung Yeon Jeon Jung Ho Choi Sun Seong Kang Yong-Hwi An Hyun Joon Shim |
| author_facet | Seung Yeon Jeon Jung Ho Choi Sun Seong Kang Yong-Hwi An Hyun Joon Shim |
| author_sort | Seung Yeon Jeon |
| collection | DOAJ |
| description | This study evaluated the efficacy of personalized neuromodulation, where treatment modalities are chosen based on the patient’s responses in a pilot trial. A total of 71 patients with tinnitus were divided into two groups: a personalized group and a randomized neuromodulation group. In the personalized group (<i>n</i> = 35), repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS) were assessed in a pilot trial, and responsive modalities were administered to 16 patients, while the non-responders (<i>n</i> = 19) were randomly assigned to rTMS, tDCS, or combined modalities. Patients in the randomized group (<i>n</i> = 36) were randomly allocated to rTMS, tDCS, or combined modalities. The Tinnitus Handicap Inventory (THI) score improvement after 10 sessions of each neuromodulation was significantly greater in the personalized group than in the randomized group (<i>p</i> = 0.043), with no significant differences in tinnitus loudness, distress, or awareness. The treatment success rate was highest in the personalized responder subgroup (92.3%), and significantly greater than that in the non-responder subgroup (53.0%; <i>p</i> = 0.042) and the randomized group (56.7%; <i>p</i> = 0.033). Personalized neuromodulation, where the treatment modality is chosen based on the patient’s responses in a pilot trial, is an advantageous strategy for treating tinnitus. |
| first_indexed | 2024-03-09T16:43:38Z |
| format | Article |
| id | doaj.art-06bff951e1a74de1a34b5199aab733ed |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T16:43:38Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-06bff951e1a74de1a34b5199aab733ed2023-11-24T14:49:02ZengMDPI AGJournal of Clinical Medicine2077-03832023-11-011222698710.3390/jcm12226987Personalized Neuromodulation: A Novel Strategy for Improving Tinnitus TreatmentSeung Yeon Jeon0Jung Ho Choi1Sun Seong Kang2Yong-Hwi An3Hyun Joon Shim4Department of Otorhinolaryngology-Head and Neck Surgery, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul 01830, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul 01830, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul 01830, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul 01830, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul 01830, Republic of KoreaThis study evaluated the efficacy of personalized neuromodulation, where treatment modalities are chosen based on the patient’s responses in a pilot trial. A total of 71 patients with tinnitus were divided into two groups: a personalized group and a randomized neuromodulation group. In the personalized group (<i>n</i> = 35), repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS) were assessed in a pilot trial, and responsive modalities were administered to 16 patients, while the non-responders (<i>n</i> = 19) were randomly assigned to rTMS, tDCS, or combined modalities. Patients in the randomized group (<i>n</i> = 36) were randomly allocated to rTMS, tDCS, or combined modalities. The Tinnitus Handicap Inventory (THI) score improvement after 10 sessions of each neuromodulation was significantly greater in the personalized group than in the randomized group (<i>p</i> = 0.043), with no significant differences in tinnitus loudness, distress, or awareness. The treatment success rate was highest in the personalized responder subgroup (92.3%), and significantly greater than that in the non-responder subgroup (53.0%; <i>p</i> = 0.042) and the randomized group (56.7%; <i>p</i> = 0.033). Personalized neuromodulation, where the treatment modality is chosen based on the patient’s responses in a pilot trial, is an advantageous strategy for treating tinnitus.https://www.mdpi.com/2077-0383/12/22/6987neuromodulationtinnitustranscranial magnetic stimulationtranscranial direct-current stimulation |
| spellingShingle | Seung Yeon Jeon Jung Ho Choi Sun Seong Kang Yong-Hwi An Hyun Joon Shim Personalized Neuromodulation: A Novel Strategy for Improving Tinnitus Treatment Journal of Clinical Medicine neuromodulation tinnitus transcranial magnetic stimulation transcranial direct-current stimulation |
| title | Personalized Neuromodulation: A Novel Strategy for Improving Tinnitus Treatment |
| title_full | Personalized Neuromodulation: A Novel Strategy for Improving Tinnitus Treatment |
| title_fullStr | Personalized Neuromodulation: A Novel Strategy for Improving Tinnitus Treatment |
| title_full_unstemmed | Personalized Neuromodulation: A Novel Strategy for Improving Tinnitus Treatment |
| title_short | Personalized Neuromodulation: A Novel Strategy for Improving Tinnitus Treatment |
| title_sort | personalized neuromodulation a novel strategy for improving tinnitus treatment |
| topic | neuromodulation tinnitus transcranial magnetic stimulation transcranial direct-current stimulation |
| url | https://www.mdpi.com/2077-0383/12/22/6987 |
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