Bacillus Cereus bacteremia complicated by brain abscess in a severely immunocompromised patient: Addressing importance of early recognition and challenges in diagnosis
Bacillus cereus (B. cereus) is a known cause of a food poisoning in the general population. However, it can cause life-threatening sepsis and shock in severely immunocompromised patients with hematologic malignancies, which frequently lead to central nervous system (CNS) infections associated with h...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | IDCases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250922001536 |
| _version_ | 1828352959766855680 |
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| author | David Schoenfeld Dasom Lee John A. Arrington John Greene Olga Klinkova |
| author_facet | David Schoenfeld Dasom Lee John A. Arrington John Greene Olga Klinkova |
| author_sort | David Schoenfeld |
| collection | DOAJ |
| description | Bacillus cereus (B. cereus) is a known cause of a food poisoning in the general population. However, it can cause life-threatening sepsis and shock in severely immunocompromised patients with hematologic malignancies, which frequently lead to central nervous system (CNS) infections associated with high mortality and morbidity. In this case report, we describe a patient with a newly diagnosed acute myeloid leukemia that underwent induction chemotherapy and developed B. cereus infection that was associated with septic shock and brain abscesses. Definitive diagnosis of multiple brain abscesses was not manifested with routine microbiological investigation but required the use of 16S ribosomal (rRNA) gene polymerase chain reaction (PCR) sequencing of the resected brain lesion. The patient was eventually treated with 8-week course of intravenous vancomycin and high-dose ciprofloxacin which led to a full recovery. This report highlights the significant risk posed by B. cereus infection in neutropenic patients, the use of 16S rRNA PCR sequencing test for definitive diagnosis and use of combination therapy for successful treatment of B. Cereus CNS infection. |
| first_indexed | 2024-04-14T02:00:53Z |
| format | Article |
| id | doaj.art-06c197f4a1b543e7ada5039ed7540379 |
| institution | Directory Open Access Journal |
| issn | 2214-2509 |
| language | English |
| last_indexed | 2024-04-14T02:00:53Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj.art-06c197f4a1b543e7ada5039ed75403792022-12-22T02:18:50ZengElsevierIDCases2214-25092022-01-0129e01525Bacillus Cereus bacteremia complicated by brain abscess in a severely immunocompromised patient: Addressing importance of early recognition and challenges in diagnosisDavid Schoenfeld0Dasom Lee1John A. Arrington2John Greene3Olga Klinkova4Department of Internal Medicine, University of South Florida, 17 Davis Blvd., Suite 308, Tampa, FL 33606, USADepartment of Internal Medicine, University of South Florida, 17 Davis Blvd., Suite 308, Tampa, FL 33606, USADepartment of Radiology, Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL 33612, USAInfectious Disease Division, Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL 33612, USAInfectious Disease Division, Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL 33612, USA; Correspondence to: Moffitt Cancer Center, 12902 USF Magnolia Dr, Tampa, FL 33612, USA.Bacillus cereus (B. cereus) is a known cause of a food poisoning in the general population. However, it can cause life-threatening sepsis and shock in severely immunocompromised patients with hematologic malignancies, which frequently lead to central nervous system (CNS) infections associated with high mortality and morbidity. In this case report, we describe a patient with a newly diagnosed acute myeloid leukemia that underwent induction chemotherapy and developed B. cereus infection that was associated with septic shock and brain abscesses. Definitive diagnosis of multiple brain abscesses was not manifested with routine microbiological investigation but required the use of 16S ribosomal (rRNA) gene polymerase chain reaction (PCR) sequencing of the resected brain lesion. The patient was eventually treated with 8-week course of intravenous vancomycin and high-dose ciprofloxacin which led to a full recovery. This report highlights the significant risk posed by B. cereus infection in neutropenic patients, the use of 16S rRNA PCR sequencing test for definitive diagnosis and use of combination therapy for successful treatment of B. Cereus CNS infection.http://www.sciencedirect.com/science/article/pii/S2214250922001536Bacillus cereusBrain abscessImmunocompromised16S rRNA PCR sequencingCNS infectionCombination antibiotic therapy |
| spellingShingle | David Schoenfeld Dasom Lee John A. Arrington John Greene Olga Klinkova Bacillus Cereus bacteremia complicated by brain abscess in a severely immunocompromised patient: Addressing importance of early recognition and challenges in diagnosis IDCases Bacillus cereus Brain abscess Immunocompromised 16S rRNA PCR sequencing CNS infection Combination antibiotic therapy |
| title | Bacillus Cereus bacteremia complicated by brain abscess in a severely immunocompromised patient: Addressing importance of early recognition and challenges in diagnosis |
| title_full | Bacillus Cereus bacteremia complicated by brain abscess in a severely immunocompromised patient: Addressing importance of early recognition and challenges in diagnosis |
| title_fullStr | Bacillus Cereus bacteremia complicated by brain abscess in a severely immunocompromised patient: Addressing importance of early recognition and challenges in diagnosis |
| title_full_unstemmed | Bacillus Cereus bacteremia complicated by brain abscess in a severely immunocompromised patient: Addressing importance of early recognition and challenges in diagnosis |
| title_short | Bacillus Cereus bacteremia complicated by brain abscess in a severely immunocompromised patient: Addressing importance of early recognition and challenges in diagnosis |
| title_sort | bacillus cereus bacteremia complicated by brain abscess in a severely immunocompromised patient addressing importance of early recognition and challenges in diagnosis |
| topic | Bacillus cereus Brain abscess Immunocompromised 16S rRNA PCR sequencing CNS infection Combination antibiotic therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2214250922001536 |
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