Anemia and hematinic deficiencies in gastric parietal cell antibody-positive and -negative oral mucosal disease patients with microcytosis
Microcytosis is defined as mean corpuscular volume (MCV) < 80 fL. This study assessed the anemia statuses and hematinic deficiencies in 30 patients with gastric parietal cell antibody-positive microcytosis (GPCA+/microcytosis) and 210 patients with GPCA-negative microcytosis (GPCA−/microcytosis)....
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| Format: | Article |
| Language: | English |
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Elsevier
2017-08-01
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| Series: | Journal of the Formosan Medical Association |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664617300682 |
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| author | Hung-Pin Lin Yu-Hsueh Wu Yi-Ping Wang Yang-Che Wu Julia Yu-Fong Chang Andy Sun |
| author_facet | Hung-Pin Lin Yu-Hsueh Wu Yi-Ping Wang Yang-Che Wu Julia Yu-Fong Chang Andy Sun |
| author_sort | Hung-Pin Lin |
| collection | DOAJ |
| description | Microcytosis is defined as mean corpuscular volume (MCV) < 80 fL. This study assessed the anemia statuses and hematinic deficiencies in 30 patients with gastric parietal cell antibody-positive microcytosis (GPCA+/microcytosis) and 210 patients with GPCA-negative microcytosis (GPCA−/microcytosis).
Methods: We measured and compared the mean red blood cell (RBC) count, MCV, and RBC distribution width (RDW), as well as blood levels of hemoglobin, iron, vitamin B12, folic acid, and homocysteine among the aforementioned patient groups and 240 healthy controls.
Results: Compared with GPCA−/microcytosis, the positive counterparts presented with a lower mean serum vitamin B12 level (marginal significance), significantly higher mean RDW and serum homocysteine level, and significantly greater frequencies of vitamin B12 deficiency and high homocysteine level. GPCA−/microcytosis patients had significantly greater frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of RBC count > 5 × 1012/L than healthy controls. Moreover, 19 of 30 GPCA+/microcytosis patients and 143 of 210 GPCA−/microcytosis patients had anemia, with iron deficiency anemia being the most common type, followed by thalassemia trait-induced anemia and microcytic anemia due to other causes.
Conclusion: We conclude that GPCA in microcytosis patients' sera may have caused significantly lower mean vitamin B12 level as well as significantly higher mean RDW and serum homocysteine level in our GPCA+/microcytosis patients than in GPCA−/microcytosis patients. Herein, iron deficiency anemia was the most common type of anemia in anemic GPCA+/microcytosis and GPCA−/microcytosis patients. |
| first_indexed | 2024-12-10T10:34:25Z |
| format | Article |
| id | doaj.art-06c3407b1c574e64afb45299da28f99f |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-10T10:34:25Z |
| publishDate | 2017-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-06c3407b1c574e64afb45299da28f99f2022-12-22T01:52:28ZengElsevierJournal of the Formosan Medical Association0929-66462017-08-01116861361910.1016/j.jfma.2017.02.001Anemia and hematinic deficiencies in gastric parietal cell antibody-positive and -negative oral mucosal disease patients with microcytosisHung-Pin Lin0Yu-Hsueh Wu1Yi-Ping Wang2Yang-Che Wu3Julia Yu-Fong Chang4Andy Sun5Department of Dentistry, MacKay Memorial Hospital, Taipei, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, TaiwanSchool of Dentistry, National Taiwan University, Taipei, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, TaiwanSchool of Dentistry, National Taiwan University, Taipei, TaiwanSchool of Dentistry, National Taiwan University, Taipei, TaiwanMicrocytosis is defined as mean corpuscular volume (MCV) < 80 fL. This study assessed the anemia statuses and hematinic deficiencies in 30 patients with gastric parietal cell antibody-positive microcytosis (GPCA+/microcytosis) and 210 patients with GPCA-negative microcytosis (GPCA−/microcytosis). Methods: We measured and compared the mean red blood cell (RBC) count, MCV, and RBC distribution width (RDW), as well as blood levels of hemoglobin, iron, vitamin B12, folic acid, and homocysteine among the aforementioned patient groups and 240 healthy controls. Results: Compared with GPCA−/microcytosis, the positive counterparts presented with a lower mean serum vitamin B12 level (marginal significance), significantly higher mean RDW and serum homocysteine level, and significantly greater frequencies of vitamin B12 deficiency and high homocysteine level. GPCA−/microcytosis patients had significantly greater frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of RBC count > 5 × 1012/L than healthy controls. Moreover, 19 of 30 GPCA+/microcytosis patients and 143 of 210 GPCA−/microcytosis patients had anemia, with iron deficiency anemia being the most common type, followed by thalassemia trait-induced anemia and microcytic anemia due to other causes. Conclusion: We conclude that GPCA in microcytosis patients' sera may have caused significantly lower mean vitamin B12 level as well as significantly higher mean RDW and serum homocysteine level in our GPCA+/microcytosis patients than in GPCA−/microcytosis patients. Herein, iron deficiency anemia was the most common type of anemia in anemic GPCA+/microcytosis and GPCA−/microcytosis patients.http://www.sciencedirect.com/science/article/pii/S0929664617300682anemiagastric parietal cell antibodyironvitamin B12homocysteinethalassemia trait |
| spellingShingle | Hung-Pin Lin Yu-Hsueh Wu Yi-Ping Wang Yang-Che Wu Julia Yu-Fong Chang Andy Sun Anemia and hematinic deficiencies in gastric parietal cell antibody-positive and -negative oral mucosal disease patients with microcytosis Journal of the Formosan Medical Association anemia gastric parietal cell antibody iron vitamin B12 homocysteine thalassemia trait |
| title | Anemia and hematinic deficiencies in gastric parietal cell antibody-positive and -negative oral mucosal disease patients with microcytosis |
| title_full | Anemia and hematinic deficiencies in gastric parietal cell antibody-positive and -negative oral mucosal disease patients with microcytosis |
| title_fullStr | Anemia and hematinic deficiencies in gastric parietal cell antibody-positive and -negative oral mucosal disease patients with microcytosis |
| title_full_unstemmed | Anemia and hematinic deficiencies in gastric parietal cell antibody-positive and -negative oral mucosal disease patients with microcytosis |
| title_short | Anemia and hematinic deficiencies in gastric parietal cell antibody-positive and -negative oral mucosal disease patients with microcytosis |
| title_sort | anemia and hematinic deficiencies in gastric parietal cell antibody positive and negative oral mucosal disease patients with microcytosis |
| topic | anemia gastric parietal cell antibody iron vitamin B12 homocysteine thalassemia trait |
| url | http://www.sciencedirect.com/science/article/pii/S0929664617300682 |
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