Signaling triggered by Thy-1 interaction with ß3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function
Thy-1 is an abundant neuronal glycoprotein in mammals. Despite such prevalence, Thy-1 function remains largely obscure in the absence of a defined ligand. Recently described evidence that Thy-1 interacts with ß3 integrin on astrocytes will be discussed. Thy-1 binding to ß3 integrin triggers tyrosine...
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| Format: | Article |
| Language: | English |
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BMC
2002-01-01
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| Series: | Biological Research |
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| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200015 |
| _version_ | 1819105397315731456 |
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| author | ANA MARIA AVALOS CECILIA V. LABRA ANDREW F.G. QUEST LISSETTE LEYTON |
| author_facet | ANA MARIA AVALOS CECILIA V. LABRA ANDREW F.G. QUEST LISSETTE LEYTON |
| author_sort | ANA MARIA AVALOS |
| collection | DOAJ |
| description | Thy-1 is an abundant neuronal glycoprotein in mammals. Despite such prevalence, Thy-1 function remains largely obscure in the absence of a defined ligand. Recently described evidence that Thy-1 interacts with ß3 integrin on astrocytes will be discussed. Thy-1 binding to ß3 integrin triggers tyrosine phosphorylation of focal adhesion proteins in astrocytes, thereby promoting focal adhesion formation, cell attachment and spreading. Thy-1 has been reported to modulate neurite outgrowth by triggering a cellular response in neurons. However, our data indicate that Thy-1 can also initiate signaling events that promote adhesion of adjacent astrocytes to the underlying surface. Preliminary results suggest that morphological changes observed in the actin cytoskeleton of astrocytes as a consequence of Thy-1 binding is mediated by small GTPases from the Rho family. Our findings argue that Thy-1 functions in a bimodal fashion, as a receptor on neuronal cells and as a ligand for ß3 integrin receptor on astrocytes. Since Thy-1 is implicated in the inhibition of neurite outgrowth, signaling events in astrocytes are likely to play an important role in this process |
| first_indexed | 2024-12-22T02:21:36Z |
| format | Article |
| id | doaj.art-06c406df9d934695a44ea3e4736f5bc4 |
| institution | Directory Open Access Journal |
| issn | 0716-9760 0717-6287 |
| language | English |
| last_indexed | 2024-12-22T02:21:36Z |
| publishDate | 2002-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Biological Research |
| spelling | doaj.art-06c406df9d934695a44ea3e4736f5bc42022-12-21T18:42:06ZengBMCBiological Research0716-97600717-62872002-01-01352231238Signaling triggered by Thy-1 interaction with ß3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 functionANA MARIA AVALOSCECILIA V. LABRAANDREW F.G. QUESTLISSETTE LEYTONThy-1 is an abundant neuronal glycoprotein in mammals. Despite such prevalence, Thy-1 function remains largely obscure in the absence of a defined ligand. Recently described evidence that Thy-1 interacts with ß3 integrin on astrocytes will be discussed. Thy-1 binding to ß3 integrin triggers tyrosine phosphorylation of focal adhesion proteins in astrocytes, thereby promoting focal adhesion formation, cell attachment and spreading. Thy-1 has been reported to modulate neurite outgrowth by triggering a cellular response in neurons. However, our data indicate that Thy-1 can also initiate signaling events that promote adhesion of adjacent astrocytes to the underlying surface. Preliminary results suggest that morphological changes observed in the actin cytoskeleton of astrocytes as a consequence of Thy-1 binding is mediated by small GTPases from the Rho family. Our findings argue that Thy-1 functions in a bimodal fashion, as a receptor on neuronal cells and as a ligand for ß3 integrin receptor on astrocytes. Since Thy-1 is implicated in the inhibition of neurite outgrowth, signaling events in astrocytes are likely to play an important role in this processhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200015Thy-1 ligand/integrinsGPI-anchored proteinsstrocytesfocal adhesion |
| spellingShingle | ANA MARIA AVALOS CECILIA V. LABRA ANDREW F.G. QUEST LISSETTE LEYTON Signaling triggered by Thy-1 interaction with ß3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function Biological Research Thy-1 ligand/integrins GPI-anchored proteins strocytes focal adhesion |
| title | Signaling triggered by Thy-1 interaction with ß3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function |
| title_full | Signaling triggered by Thy-1 interaction with ß3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function |
| title_fullStr | Signaling triggered by Thy-1 interaction with ß3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function |
| title_full_unstemmed | Signaling triggered by Thy-1 interaction with ß3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function |
| title_short | Signaling triggered by Thy-1 interaction with ß3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function |
| title_sort | signaling triggered by thy 1 interaction with ss3 integrin on astrocytes is an essential step towards unraveling neuronal thy 1 function |
| topic | Thy-1 ligand/integrins GPI-anchored proteins strocytes focal adhesion |
| url | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200015 |
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