The Characteristics of TB Epidemic and TB/HIV Co-Infection Epidemic: A 2007-2013 Retrospective Study in Urumqi, Xinjiang Province, China.
This study was aimed to find out epidemiologic characteristic of tuberculosis (TB) cases, and Human Immunodeficiency Virus (HIV) positive cases among TB patients (TB/HIV co-infection) through demographic, temporal, and spatial study in Urumqi.Descriptive statistics and multivariate logistic regressi...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5074460?pdf=render |
| _version_ | 1818541348544839680 |
|---|---|
| author | Wang Wei Zhang Wei-Sheng Alayi Ahan Yan Ci Zhang Wei-Wen Cao Ming-Qin |
| author_facet | Wang Wei Zhang Wei-Sheng Alayi Ahan Yan Ci Zhang Wei-Wen Cao Ming-Qin |
| author_sort | Wang Wei |
| collection | DOAJ |
| description | This study was aimed to find out epidemiologic characteristic of tuberculosis (TB) cases, and Human Immunodeficiency Virus (HIV) positive cases among TB patients (TB/HIV co-infection) through demographic, temporal, and spatial study in Urumqi.Descriptive statistics and multivariate logistic regression were applied to identify the epidemiologic characteristics and risk factors of TB epidemic and TB/HIV co-infection epidemic. All addresses of each TB case, TB/HIV co-infection case, and administrative street were transformed into geographical coordinate. Subsequently, the geocoded address for 82 streets was transformed into a dot map used as the basis of spatial datasets. In addition, the paper also used quantile map and the spatial scan statistic in order to identify the spatial distribution and spatial clusters of TB epidemic and TB/HIV co-infection epidemic.There was a declining trend of the notification rates of TB epidemic from 2007 to 2009, as well as a rising trend from 2010 to 2013. However, the notification rates of TB/HIV co-infection epidemic showed a rising trend from 2007 to 2010, and a declining trend from 2011 to 2013. Moreover, a significant share of TB epidemic and TB/HIV co-infection epidemic happened between the age of 15 to 45 years old, indicating an increase in risk of TB and TB/HIV infection. It is worth noting that the risk of HIV infection for male TB patients was 2.947 times (95% CI [2.178, 3.988]) than that of female patients. Han ethnicity and Uygur ethnicity in urban region accounted for a large proportion of total TB and TB/HIV co-infection cases. Most of the TB cases of minorities in Urumqi showed a statistically significant increase in risk of HIV infection than Han ethnicity in Urumqi. In addition, the spatial distribution of TB epidemic and TB/HIV co-infection epidemic was highly skewed. Most of the local clusters were located in urban area and rural-urban continuum where showed an increase in risk of TB and TB/HIV infection.The epidemiologic and spatial-temporal analysis of TB epidemic and TB/HIV co-infection epidemic demonstrates a potential connection between TB and HIV in Urumqi. Demographic, temporal, geographic factors are the reasons of causing TB and TB/HIV co-infection epidemic. |
| first_indexed | 2024-12-11T22:08:06Z |
| format | Article |
| id | doaj.art-06c53bbb27be4a419dd6bddebf9d4381 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T22:08:06Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-06c53bbb27be4a419dd6bddebf9d43812022-12-22T00:48:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011110e016494710.1371/journal.pone.0164947The Characteristics of TB Epidemic and TB/HIV Co-Infection Epidemic: A 2007-2013 Retrospective Study in Urumqi, Xinjiang Province, China.Wang WeiZhang Wei-ShengAlayi AhanYan CiZhang Wei-WenCao Ming-QinThis study was aimed to find out epidemiologic characteristic of tuberculosis (TB) cases, and Human Immunodeficiency Virus (HIV) positive cases among TB patients (TB/HIV co-infection) through demographic, temporal, and spatial study in Urumqi.Descriptive statistics and multivariate logistic regression were applied to identify the epidemiologic characteristics and risk factors of TB epidemic and TB/HIV co-infection epidemic. All addresses of each TB case, TB/HIV co-infection case, and administrative street were transformed into geographical coordinate. Subsequently, the geocoded address for 82 streets was transformed into a dot map used as the basis of spatial datasets. In addition, the paper also used quantile map and the spatial scan statistic in order to identify the spatial distribution and spatial clusters of TB epidemic and TB/HIV co-infection epidemic.There was a declining trend of the notification rates of TB epidemic from 2007 to 2009, as well as a rising trend from 2010 to 2013. However, the notification rates of TB/HIV co-infection epidemic showed a rising trend from 2007 to 2010, and a declining trend from 2011 to 2013. Moreover, a significant share of TB epidemic and TB/HIV co-infection epidemic happened between the age of 15 to 45 years old, indicating an increase in risk of TB and TB/HIV infection. It is worth noting that the risk of HIV infection for male TB patients was 2.947 times (95% CI [2.178, 3.988]) than that of female patients. Han ethnicity and Uygur ethnicity in urban region accounted for a large proportion of total TB and TB/HIV co-infection cases. Most of the TB cases of minorities in Urumqi showed a statistically significant increase in risk of HIV infection than Han ethnicity in Urumqi. In addition, the spatial distribution of TB epidemic and TB/HIV co-infection epidemic was highly skewed. Most of the local clusters were located in urban area and rural-urban continuum where showed an increase in risk of TB and TB/HIV infection.The epidemiologic and spatial-temporal analysis of TB epidemic and TB/HIV co-infection epidemic demonstrates a potential connection between TB and HIV in Urumqi. Demographic, temporal, geographic factors are the reasons of causing TB and TB/HIV co-infection epidemic.http://europepmc.org/articles/PMC5074460?pdf=render |
| spellingShingle | Wang Wei Zhang Wei-Sheng Alayi Ahan Yan Ci Zhang Wei-Wen Cao Ming-Qin The Characteristics of TB Epidemic and TB/HIV Co-Infection Epidemic: A 2007-2013 Retrospective Study in Urumqi, Xinjiang Province, China. PLoS ONE |
| title | The Characteristics of TB Epidemic and TB/HIV Co-Infection Epidemic: A 2007-2013 Retrospective Study in Urumqi, Xinjiang Province, China. |
| title_full | The Characteristics of TB Epidemic and TB/HIV Co-Infection Epidemic: A 2007-2013 Retrospective Study in Urumqi, Xinjiang Province, China. |
| title_fullStr | The Characteristics of TB Epidemic and TB/HIV Co-Infection Epidemic: A 2007-2013 Retrospective Study in Urumqi, Xinjiang Province, China. |
| title_full_unstemmed | The Characteristics of TB Epidemic and TB/HIV Co-Infection Epidemic: A 2007-2013 Retrospective Study in Urumqi, Xinjiang Province, China. |
| title_short | The Characteristics of TB Epidemic and TB/HIV Co-Infection Epidemic: A 2007-2013 Retrospective Study in Urumqi, Xinjiang Province, China. |
| title_sort | characteristics of tb epidemic and tb hiv co infection epidemic a 2007 2013 retrospective study in urumqi xinjiang province china |
| url | http://europepmc.org/articles/PMC5074460?pdf=render |
| work_keys_str_mv | AT wangwei thecharacteristicsoftbepidemicandtbhivcoinfectionepidemica20072013retrospectivestudyinurumqixinjiangprovincechina AT zhangweisheng thecharacteristicsoftbepidemicandtbhivcoinfectionepidemica20072013retrospectivestudyinurumqixinjiangprovincechina AT alayiahan thecharacteristicsoftbepidemicandtbhivcoinfectionepidemica20072013retrospectivestudyinurumqixinjiangprovincechina AT yanci thecharacteristicsoftbepidemicandtbhivcoinfectionepidemica20072013retrospectivestudyinurumqixinjiangprovincechina AT zhangweiwen thecharacteristicsoftbepidemicandtbhivcoinfectionepidemica20072013retrospectivestudyinurumqixinjiangprovincechina AT caomingqin thecharacteristicsoftbepidemicandtbhivcoinfectionepidemica20072013retrospectivestudyinurumqixinjiangprovincechina AT wangwei characteristicsoftbepidemicandtbhivcoinfectionepidemica20072013retrospectivestudyinurumqixinjiangprovincechina AT zhangweisheng characteristicsoftbepidemicandtbhivcoinfectionepidemica20072013retrospectivestudyinurumqixinjiangprovincechina AT alayiahan characteristicsoftbepidemicandtbhivcoinfectionepidemica20072013retrospectivestudyinurumqixinjiangprovincechina AT yanci characteristicsoftbepidemicandtbhivcoinfectionepidemica20072013retrospectivestudyinurumqixinjiangprovincechina AT zhangweiwen characteristicsoftbepidemicandtbhivcoinfectionepidemica20072013retrospectivestudyinurumqixinjiangprovincechina AT caomingqin characteristicsoftbepidemicandtbhivcoinfectionepidemica20072013retrospectivestudyinurumqixinjiangprovincechina |