Plasma Endothelin-1 Levels in Preterm Neonatal Infants with Acute Respiratory Failure
Increased pulmonary vascular resistance in preterm infants is associated with acute respiratory failure (ARF) and at the same time endothelin-1 (E-1) plays an important role in neonatal pulmonary vascular responsiveness. Methods. Endothelin-1 levels were measured in two blood samples in 12 preterm i...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2008-06-01
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| Series: | Общая реаниматология |
| Online Access: | https://www.reanimatology.com/rmt/article/view/751 |
| _version_ | 1797874382556626944 |
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| author | D. V. Dmitriyev V. S. Konoplitsky K. T. Bertsun |
| author_facet | D. V. Dmitriyev V. S. Konoplitsky K. T. Bertsun |
| author_sort | D. V. Dmitriyev |
| collection | DOAJ |
| description | Increased pulmonary vascular resistance in preterm infants is associated with acute respiratory failure (ARF) and at the same time endothelin-1 (E-1) plays an important role in neonatal pulmonary vascular responsiveness. Methods. Endothelin-1 levels were measured in two blood samples in 12 preterm infants with ARF and in 12 controls (at 32.2±1.3 and 29.8±1.2 weeks of gestation, respectively) by enzyme immunoassay. For this, the first and second blood samples were taken at 18 to 40 hours after birth. Results. The plasma level of E-1 in the first sample did not differ between the neonates of both groups. In the second sample, significantly higher E-1 concentrations were observed in the newborns with ARF than in the controls. In the first sample, E-1 concentration were higher than in the second one in both groups (p<0.001). There was a significant positive correlation between the second E-1 sample and the SNAPPE 2 scale rating (r=0.38; p=0.02). The plasma level of E-1 in the first sample did not differ in both groups (11.9 and 12.2 pg/ml, respectively). Conclusion. Neonates with and without ARF had the similar plasma E-1 levels in the first sample, by taking into account the fact that the E-1 levels were higher in ARF than in the controls at 18 to 40 hour after birth. Increased vascular resistance in ARF may be associated with the high level of E-1. Key words: endothe-lin-1, acute respiratory failure. |
| first_indexed | 2024-04-10T01:30:01Z |
| format | Article |
| id | doaj.art-06c613d639b641409cc558d71d685719 |
| institution | Directory Open Access Journal |
| issn | 1813-9779 2411-7110 |
| language | English |
| last_indexed | 2024-04-10T01:30:01Z |
| publishDate | 2008-06-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj.art-06c613d639b641409cc558d71d6857192023-03-13T09:32:48ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102008-06-014310.15360/1813-9779-2008-3-56751Plasma Endothelin-1 Levels in Preterm Neonatal Infants with Acute Respiratory FailureD. V. DmitriyevV. S. KonoplitskyK. T. BertsunIncreased pulmonary vascular resistance in preterm infants is associated with acute respiratory failure (ARF) and at the same time endothelin-1 (E-1) plays an important role in neonatal pulmonary vascular responsiveness. Methods. Endothelin-1 levels were measured in two blood samples in 12 preterm infants with ARF and in 12 controls (at 32.2±1.3 and 29.8±1.2 weeks of gestation, respectively) by enzyme immunoassay. For this, the first and second blood samples were taken at 18 to 40 hours after birth. Results. The plasma level of E-1 in the first sample did not differ between the neonates of both groups. In the second sample, significantly higher E-1 concentrations were observed in the newborns with ARF than in the controls. In the first sample, E-1 concentration were higher than in the second one in both groups (p<0.001). There was a significant positive correlation between the second E-1 sample and the SNAPPE 2 scale rating (r=0.38; p=0.02). The plasma level of E-1 in the first sample did not differ in both groups (11.9 and 12.2 pg/ml, respectively). Conclusion. Neonates with and without ARF had the similar plasma E-1 levels in the first sample, by taking into account the fact that the E-1 levels were higher in ARF than in the controls at 18 to 40 hour after birth. Increased vascular resistance in ARF may be associated with the high level of E-1. Key words: endothe-lin-1, acute respiratory failure.https://www.reanimatology.com/rmt/article/view/751 |
| spellingShingle | D. V. Dmitriyev V. S. Konoplitsky K. T. Bertsun Plasma Endothelin-1 Levels in Preterm Neonatal Infants with Acute Respiratory Failure Общая реаниматология |
| title | Plasma Endothelin-1 Levels in Preterm Neonatal Infants with Acute Respiratory Failure |
| title_full | Plasma Endothelin-1 Levels in Preterm Neonatal Infants with Acute Respiratory Failure |
| title_fullStr | Plasma Endothelin-1 Levels in Preterm Neonatal Infants with Acute Respiratory Failure |
| title_full_unstemmed | Plasma Endothelin-1 Levels in Preterm Neonatal Infants with Acute Respiratory Failure |
| title_short | Plasma Endothelin-1 Levels in Preterm Neonatal Infants with Acute Respiratory Failure |
| title_sort | plasma endothelin 1 levels in preterm neonatal infants with acute respiratory failure |
| url | https://www.reanimatology.com/rmt/article/view/751 |
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