Resveratrol Inhibits Oxidative Stress and Regulates M1/M2-Type Polarization of Microglia via Mediation of the Nrf2/Shh Signaling Cascade after OGD/R Injury In Vitro

Resveratrol Inhibits Oxidative Stress and Regulates M1/M2-Type Polarization of Microglia via Mediation of the Nrf2/Shh Signaling Cascade after OGD/R Injury In Vitro

Aims: Microglia are closely related to the occurrence and development of oxidative stress. Cerebral ischemia leads to abnormal activation of microglia. Resveratrol can regulate M1/M2-type microglia polarization, but the underlying mechanism is not well understood, although the Nrf2 and Shh signaling...

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Bibliographic Details
Main Authors: Jie Liu, Hongyan Liao, Yue Chen, Huimin Zhu, Xuemei Li, Jing Liu, Qin Xiang, Fanling Zeng, Qin Yang
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Journal of Personalized Medicine
Subjects:
resveratrol
microglia
polarization
oxidative stress
Nrf2 signaling
Shh signaling
Online Access:https://www.mdpi.com/2075-4426/12/12/2087

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