Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture
How CD8+ T cell identity is maintained after exit from the thymus is not fully established. Here the authors use multiomics approaches including Hi-C to show that Tcf1 and Lef1 prevent aberrant expression of lineage-inappropriate genes by organizing three-dimensional genomic architecture in CD8+ T c...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26159-1 |
| _version_ | 1818691863330160640 |
|---|---|
| author | Qiang Shan Xiang Li Xia Chen Zhouhao Zeng Shaoqi Zhu Kexin Gai Weiqun Peng Hai-Hui Xue |
| author_facet | Qiang Shan Xiang Li Xia Chen Zhouhao Zeng Shaoqi Zhu Kexin Gai Weiqun Peng Hai-Hui Xue |
| author_sort | Qiang Shan |
| collection | DOAJ |
| description | How CD8+ T cell identity is maintained after exit from the thymus is not fully established. Here the authors use multiomics approaches including Hi-C to show that Tcf1 and Lef1 prevent aberrant expression of lineage-inappropriate genes by organizing three-dimensional genomic architecture in CD8+ T cells. |
| first_indexed | 2024-12-17T12:48:39Z |
| format | Article |
| id | doaj.art-06c9799f7b944534ab901ab6e4e9438f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T12:48:39Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-06c9799f7b944534ab901ab6e4e9438f2022-12-21T21:47:39ZengNature PortfolioNature Communications2041-17232021-10-0112112010.1038/s41467-021-26159-1Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architectureQiang Shan0Xiang Li1Xia Chen2Zhouhao Zeng3Shaoqi Zhu4Kexin Gai5Weiqun Peng6Hai-Hui Xue7Center for Discovery and Innovation, Hackensack University Medical CenterDepartment of Physics, The George Washington UniversityDepartment of Critical Care Medicine, Fuxing Hospital, Capital Medical UniversityDepartment of Physics, The George Washington UniversityDepartment of Physics, The George Washington UniversityCenter for Discovery and Innovation, Hackensack University Medical CenterDepartment of Physics, The George Washington UniversityCenter for Discovery and Innovation, Hackensack University Medical CenterHow CD8+ T cell identity is maintained after exit from the thymus is not fully established. Here the authors use multiomics approaches including Hi-C to show that Tcf1 and Lef1 prevent aberrant expression of lineage-inappropriate genes by organizing three-dimensional genomic architecture in CD8+ T cells.https://doi.org/10.1038/s41467-021-26159-1 |
| spellingShingle | Qiang Shan Xiang Li Xia Chen Zhouhao Zeng Shaoqi Zhu Kexin Gai Weiqun Peng Hai-Hui Xue Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture Nature Communications |
| title | Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture |
| title_full | Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture |
| title_fullStr | Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture |
| title_full_unstemmed | Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture |
| title_short | Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture |
| title_sort | tcf1 and lef1 provide constant supervision to mature cd8 t cell identity and function by organizing genomic architecture |
| url | https://doi.org/10.1038/s41467-021-26159-1 |
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