Follicular lymphoma patients with a high FLIPI score and a high tumor burden: A risk stratification model
Background/Aim. The widely accepted Follicular Lymphoma International Prognostic Index (FLIPI) divides patients into three risk groups based on the score of adverse prognostic factors. The estimated 5-year survival in patients with a high FLIPI score is around 50%. The aim of this study was...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2015-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501501026A.pdf |
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| author | Anđelić Boško Todorović-Balint Milena Antić Darko Bila Jelena Đurašinović Vladislava Mihaljević Biljana |
| author_facet | Anđelić Boško Todorović-Balint Milena Antić Darko Bila Jelena Đurašinović Vladislava Mihaljević Biljana |
| author_sort | Anđelić Boško |
| collection | DOAJ |
| description | Background/Aim. The widely accepted Follicular Lymphoma International
Prognostic Index (FLIPI) divides patients into three risk groups based on the
score of adverse prognostic factors. The estimated 5-year survival in
patients with a high FLIPI score is around 50%. The aim of this study was to
analyse the prognostic value of clinical and laboratory parameters that are
not included in the FLIPI and the New Prognostic Index for Follicular
Lymphoma developed by the International Follicular Lymphoma Prognostic Factor
Project (FLIPI2) indices, in follicular lymphoma (FL) patients with a high
FLIPI score and high tumor burden. Methods. The retrospective analysis
included 57 newly diagnosed patients with FL, a high FLIPI score and a high
tumor burden. All the patients were diagnosed and treated between April 2000
and June 2007 at the Clinic for Hematology, Clinical Center of Serbia,
Belgrade. Results. The patients with a histological grade > 1, erythrocyte
sedimentation rate (ESR) ± 45 mm/h and hypoalbuminemia had a significantly
worse overall survival (p = 0.015; p = 0.001; p = 0.008, respectively), while
there was a tendency toward worse overall survival in the patients with an
Eastern Cooperative Oncology Group (ECOG) > 1 (p = 0.075). Multivariate Cox
regression analysis identified a histological grade > 1, ESR ± 45 mm/h and
hypoalbuminemia as independent risk factors for a poor outcome. Based on a
cumulative score of unfavourable prognostic factors, patients who had 0 or 1
unfavourable factors had a significantly better 5-year overall survival
compared to patients with 2 or 3 risk factors (75% vs 24.1%, p = 0.000).
Conclusion. The obtained results suggest that from the examined prognostic
parameters histological grade > 1, ESR ± 45 mm/h and hypoalbuminemia can
contribute in defining patients who need more aggressive initial treatment
approach, if two or three of these parameters are present on presentation. |
| first_indexed | 2024-12-20T04:07:36Z |
| format | Article |
| id | doaj.art-06c99383544a464491ddae812df61af4 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-12-20T04:07:36Z |
| publishDate | 2015-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-06c99383544a464491ddae812df61af42022-12-21T19:53:59ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502015-01-01721263210.2298/VSP1501026A0042-84501501026AFollicular lymphoma patients with a high FLIPI score and a high tumor burden: A risk stratification modelAnđelić Boško0Todorović-Balint Milena1Antić Darko2Bila Jelena3Đurašinović Vladislava4Mihaljević Biljana5Clinical Center of Serbia, Clinic for Hematology, BelgradeClinical Center of Serbia, Clinic for Hematology, Belgrade + Faculty of Medicine, BelgradeClinical Center of Serbia, Clinic for Hematology, Belgrade + Faculty of Medicine, BelgradeClinical Center of Serbia, Clinic for Hematology, Belgrade + Faculty of Medicine, BelgradeClinical Center of Serbia, Clinic for Hematology, BelgradeClinical Center of Serbia, Clinic for Hematology, Belgrade + Faculty of Medicine, BelgradeBackground/Aim. The widely accepted Follicular Lymphoma International Prognostic Index (FLIPI) divides patients into three risk groups based on the score of adverse prognostic factors. The estimated 5-year survival in patients with a high FLIPI score is around 50%. The aim of this study was to analyse the prognostic value of clinical and laboratory parameters that are not included in the FLIPI and the New Prognostic Index for Follicular Lymphoma developed by the International Follicular Lymphoma Prognostic Factor Project (FLIPI2) indices, in follicular lymphoma (FL) patients with a high FLIPI score and high tumor burden. Methods. The retrospective analysis included 57 newly diagnosed patients with FL, a high FLIPI score and a high tumor burden. All the patients were diagnosed and treated between April 2000 and June 2007 at the Clinic for Hematology, Clinical Center of Serbia, Belgrade. Results. The patients with a histological grade > 1, erythrocyte sedimentation rate (ESR) ± 45 mm/h and hypoalbuminemia had a significantly worse overall survival (p = 0.015; p = 0.001; p = 0.008, respectively), while there was a tendency toward worse overall survival in the patients with an Eastern Cooperative Oncology Group (ECOG) > 1 (p = 0.075). Multivariate Cox regression analysis identified a histological grade > 1, ESR ± 45 mm/h and hypoalbuminemia as independent risk factors for a poor outcome. Based on a cumulative score of unfavourable prognostic factors, patients who had 0 or 1 unfavourable factors had a significantly better 5-year overall survival compared to patients with 2 or 3 risk factors (75% vs 24.1%, p = 0.000). Conclusion. The obtained results suggest that from the examined prognostic parameters histological grade > 1, ESR ± 45 mm/h and hypoalbuminemia can contribute in defining patients who need more aggressive initial treatment approach, if two or three of these parameters are present on presentation.http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501501026A.pdflymphomafollicularantineoplastic combined chemotherapy protocolsprognosis |
| spellingShingle | Anđelić Boško Todorović-Balint Milena Antić Darko Bila Jelena Đurašinović Vladislava Mihaljević Biljana Follicular lymphoma patients with a high FLIPI score and a high tumor burden: A risk stratification model Vojnosanitetski Pregled lymphoma follicular antineoplastic combined chemotherapy protocols prognosis |
| title | Follicular lymphoma patients with a high FLIPI score and a high tumor burden: A risk stratification model |
| title_full | Follicular lymphoma patients with a high FLIPI score and a high tumor burden: A risk stratification model |
| title_fullStr | Follicular lymphoma patients with a high FLIPI score and a high tumor burden: A risk stratification model |
| title_full_unstemmed | Follicular lymphoma patients with a high FLIPI score and a high tumor burden: A risk stratification model |
| title_short | Follicular lymphoma patients with a high FLIPI score and a high tumor burden: A risk stratification model |
| title_sort | follicular lymphoma patients with a high flipi score and a high tumor burden a risk stratification model |
| topic | lymphoma follicular antineoplastic combined chemotherapy protocols prognosis |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501501026A.pdf |
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