Lipid droplet-based storage fat metabolism in Drosophila
The fruit fly Drosophila melanogaster is an emerging model system in lipid metabolism research. Lipid droplets are omnipresent and dynamically regulated organelles found in various cell types throughout the complex life cycle of this insect. The vital importance of lipid droplets as energy resources...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-08-01
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| Series: | Journal of Lipid Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520418474 |
| _version_ | 1828942346028318720 |
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| author | Ronald P. Kühnlein |
| author_facet | Ronald P. Kühnlein |
| author_sort | Ronald P. Kühnlein |
| collection | DOAJ |
| description | The fruit fly Drosophila melanogaster is an emerging model system in lipid metabolism research. Lipid droplets are omnipresent and dynamically regulated organelles found in various cell types throughout the complex life cycle of this insect. The vital importance of lipid droplets as energy resources and storage compartments for lipoanabolic components has recently attracted research attention to the basic enzymatic machinery, which controls the delicate balance between triacylglycerol deposition and mobilization in flies. This review aims to present current insights in experimentally supported and inferred biological functions of lipogenic and lipolytic enzymes as well as regulatory proteins, which control the lipid droplet-based storage fat turnover in Drosophila. |
| first_indexed | 2024-12-14T03:53:30Z |
| format | Article |
| id | doaj.art-06ccdde59e524180be8fb7529c0f94f2 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-14T03:53:30Z |
| publishDate | 2012-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-06ccdde59e524180be8fb7529c0f94f22022-12-21T23:18:09ZengElsevierJournal of Lipid Research0022-22752012-08-0153814301436Lipid droplet-based storage fat metabolism in DrosophilaRonald P. Kühnlein0To whom correspondence should be addressed. e-mail: rkuehnl@gwdg.de.; To whom correspondence should be addressed. e-mail: rkuehnl@gwdg.de.; Research Group Molecular Physiology, Department of Molecular Developmental Biology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, GermanyThe fruit fly Drosophila melanogaster is an emerging model system in lipid metabolism research. Lipid droplets are omnipresent and dynamically regulated organelles found in various cell types throughout the complex life cycle of this insect. The vital importance of lipid droplets as energy resources and storage compartments for lipoanabolic components has recently attracted research attention to the basic enzymatic machinery, which controls the delicate balance between triacylglycerol deposition and mobilization in flies. This review aims to present current insights in experimentally supported and inferred biological functions of lipogenic and lipolytic enzymes as well as regulatory proteins, which control the lipid droplet-based storage fat turnover in Drosophila.http://www.sciencedirect.com/science/article/pii/S0022227520418474lipolysistriacylglycerolsynthesis |
| spellingShingle | Ronald P. Kühnlein Lipid droplet-based storage fat metabolism in Drosophila Journal of Lipid Research lipolysis triacylglycerol synthesis |
| title | Lipid droplet-based storage fat metabolism in Drosophila |
| title_full | Lipid droplet-based storage fat metabolism in Drosophila |
| title_fullStr | Lipid droplet-based storage fat metabolism in Drosophila |
| title_full_unstemmed | Lipid droplet-based storage fat metabolism in Drosophila |
| title_short | Lipid droplet-based storage fat metabolism in Drosophila |
| title_sort | lipid droplet based storage fat metabolism in drosophila |
| topic | lipolysis triacylglycerol synthesis |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520418474 |
| work_keys_str_mv | AT ronaldpkuhnlein lipiddropletbasedstoragefatmetabolismindrosophila |