Liver‐Inspired Polyetherketoneketone Scaffolds Simulate Regenerative Signals and Mobilize Anti‐Inflammatory Reserves to Reprogram Macrophage Metabolism for Boosted Osteoporotic Osseointegration

Liver‐Inspired Polyetherketoneketone Scaffolds Simulate Regenerative Signals and Mobilize Anti‐Inflammatory Reserves to Reprogram Macrophage Metabolism for Boosted Osteoporotic Osseointegration

Abstract Tissue regeneration is regulated by morphological clues of implants in bone defect repair. Engineered morphology can boost regenerative biocascades that conquer challenges such as material bioinertness and pathological microenvironments. Herein, a correlation between the liver extracellular...

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Bibliographic Details
Main Authors: Hao Gu, Yuhui Zhu, Jiawei Yang, Ruixue Jiang, Yuwei Deng, Anshuo Li, Yingjing Fang, Qianju Wu, Honghuan Tu, Haishuang Chang, Jin Wen, Xinquan Jiang
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Advanced Science
Subjects:
arginase‐2
biomimetic surface modification
macrophage metabolic reprogramming
osseointegration
polyetherketoneketone
Online Access:https://doi.org/10.1002/advs.202302136

Internet

https://doi.org/10.1002/advs.202302136

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