Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues
Chorioallantoic membrane assay (CAM assay) using fertilized chicken eggs has been used for the study of tumor formation, angiogenesis and metastasis. Recently, there is growing realization that this system provides a valuable assay for a patient-derived tumor model. Several reports establish that tu...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-05-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/8/5/440 |
| _version_ | 1827836202095476736 |
|---|---|
| author | Aoi Komatsu Kotaro Matsumoto Tomoki Saito Manabu Muto Fuyuhiko Tamanoi |
| author_facet | Aoi Komatsu Kotaro Matsumoto Tomoki Saito Manabu Muto Fuyuhiko Tamanoi |
| author_sort | Aoi Komatsu |
| collection | DOAJ |
| description | Chorioallantoic membrane assay (CAM assay) using fertilized chicken eggs has been used for the study of tumor formation, angiogenesis and metastasis. Recently, there is growing realization that this system provides a valuable assay for a patient-derived tumor model. Several reports establish that tumor samples from cancer patients can be used to reproduce tumor in the chicken egg. High transplantation efficiency has been achieved. In this review, we discuss examples of transplanting patient tumors. We then discuss critical issues that need to be addressed to pursue this line of experiments. The patient-derived chicken egg model (PDcE model) has an advantage over other models in its rapid tumor formation. This raises the possibility that the PDcE model is valuable for identifying optimum drug for each individual patient. |
| first_indexed | 2024-03-12T06:23:36Z |
| format | Article |
| id | doaj.art-06cd98d9821244c28ec496449c9121d0 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:23:36Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-06cd98d9821244c28ec496449c9121d02023-09-03T02:04:38ZengMDPI AGCells2073-44092019-05-018544010.3390/cells8050440cells8050440Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical IssuesAoi Komatsu0Kotaro Matsumoto1Tomoki Saito2Manabu Muto3Fuyuhiko Tamanoi4Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto 606-8501, JapanInstitute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto 606-8501, JapanDepartment of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, JapanDepartment of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, JapanInstitute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto 606-8501, JapanChorioallantoic membrane assay (CAM assay) using fertilized chicken eggs has been used for the study of tumor formation, angiogenesis and metastasis. Recently, there is growing realization that this system provides a valuable assay for a patient-derived tumor model. Several reports establish that tumor samples from cancer patients can be used to reproduce tumor in the chicken egg. High transplantation efficiency has been achieved. In this review, we discuss examples of transplanting patient tumors. We then discuss critical issues that need to be addressed to pursue this line of experiments. The patient-derived chicken egg model (PDcE model) has an advantage over other models in its rapid tumor formation. This raises the possibility that the PDcE model is valuable for identifying optimum drug for each individual patient.https://www.mdpi.com/2073-4409/8/5/440CAM assaytumor tissueimmunohistochemistrypatient tumorH&E stainingangiogenesisprecision medicinetailor-made drug |
| spellingShingle | Aoi Komatsu Kotaro Matsumoto Tomoki Saito Manabu Muto Fuyuhiko Tamanoi Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues Cells CAM assay tumor tissue immunohistochemistry patient tumor H& E staining angiogenesis precision medicine tailor-made drug |
| title | Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues |
| title_full | Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues |
| title_fullStr | Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues |
| title_full_unstemmed | Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues |
| title_short | Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues |
| title_sort | patient derived chicken egg tumor model pdce model current status and critical issues |
| topic | CAM assay tumor tissue immunohistochemistry patient tumor H& E staining angiogenesis precision medicine tailor-made drug |
| url | https://www.mdpi.com/2073-4409/8/5/440 |
| work_keys_str_mv | AT aoikomatsu patientderivedchickeneggtumormodelpdcemodelcurrentstatusandcriticalissues AT kotaromatsumoto patientderivedchickeneggtumormodelpdcemodelcurrentstatusandcriticalissues AT tomokisaito patientderivedchickeneggtumormodelpdcemodelcurrentstatusandcriticalissues AT manabumuto patientderivedchickeneggtumormodelpdcemodelcurrentstatusandcriticalissues AT fuyuhikotamanoi patientderivedchickeneggtumormodelpdcemodelcurrentstatusandcriticalissues |