Role of serotonin on pituitary-thyroid functions and antioxidants in diabetic male rats
Diabetes mellitus causes an increase in oxidative stress. Serotonin is a hormone its level in circulation reduced in diabetes; recently, it has been found to possess antioxidant qualities. The purpose of the study was to look at the impact of diabetes on pituitary-thyroid functioning, and serotonin...
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| Format: | Article |
| Language: | English |
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Faculty of Veterinary Medicine, University of Kufa
2023-12-01
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| Series: | Kufa Journal for Veterinary Medical Sciences |
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| Online Access: | https://journal.uokufa.edu.iq/index.php/kjvs/article/view/12699 |
| _version_ | 1797362685100163072 |
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| author | Sumayah Faruq Kasim Fouad Ziedan Hamzah |
| author_facet | Sumayah Faruq Kasim Fouad Ziedan Hamzah |
| author_sort | Sumayah Faruq Kasim |
| collection | DOAJ |
| description |
Diabetes mellitus causes an increase in oxidative stress. Serotonin is a hormone its level in circulation reduced in diabetes; recently, it has been found to possess antioxidant qualities. The purpose of the study was to look at the impact of diabetes on pituitary-thyroid functioning, and serotonin role in modulating these effects in a streptozotocin-induced diabetes mellitus rat model. The thirty-tow healthy male rats with a body weight of 180-200 gm were split equally into 4 groups, group [1[: control, group [2]: Serotonin, group [3]: diabetic, and group [4]: Serotonin-diabetic. The rats were weighed and serum levels of glucose, insulin, malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, serotonin, thyroid stimulating hormone, thyroxine, and triiodothyronine were measured. Our results presented that there was a significant increase in T3, T4, glucose, and MDA in the diabetic group compared to the control, while a significant decrease in T3, and T4, glucose, and MDA in the Serotonin with diabetic group compared to diabetic group. Furthermore, a significant decrease in TSH, serotonin, insulin and GPX, CAT, and SOD antioxidants in the diabetic group compared to control, while a significant increase in serum TSH, serotonin, insulin and CAT, GPX and SOD antioxidants in the Serotonin+diabetic group compared to diabetic group as well as a significant increase in serum insulin in the Serotonin group compared to all other groups. Serotonin plays a protective role against diabetes-induced and pituitary-thyroid disorder caused by diabetes which might be because of its antioxidant qualities and ability to maintain glucose and insulin balance.
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| first_indexed | 2024-03-08T16:11:00Z |
| format | Article |
| id | doaj.art-06cfa5a3423d44608676f7b117e15176 |
| institution | Directory Open Access Journal |
| issn | 2077-9798 2959-8478 |
| language | English |
| last_indexed | 2024-03-08T16:11:00Z |
| publishDate | 2023-12-01 |
| publisher | Faculty of Veterinary Medicine, University of Kufa |
| record_format | Article |
| series | Kufa Journal for Veterinary Medical Sciences |
| spelling | doaj.art-06cfa5a3423d44608676f7b117e151762024-01-07T16:34:18ZengFaculty of Veterinary Medicine, University of KufaKufa Journal for Veterinary Medical Sciences2077-97982959-84782023-12-0114210.36326/kjvs/2023/v14i212699Role of serotonin on pituitary-thyroid functions and antioxidants in diabetic male ratsSumayah Faruq Kasim0https://orcid.org/0000-0003-1809-6832Fouad Ziedan Hamzah1College of Health and Medical Techniques, Middle Technical University, Iraq.Faculty of Veterinary Medicine, University of Kufa, Iraq. Diabetes mellitus causes an increase in oxidative stress. Serotonin is a hormone its level in circulation reduced in diabetes; recently, it has been found to possess antioxidant qualities. The purpose of the study was to look at the impact of diabetes on pituitary-thyroid functioning, and serotonin role in modulating these effects in a streptozotocin-induced diabetes mellitus rat model. The thirty-tow healthy male rats with a body weight of 180-200 gm were split equally into 4 groups, group [1[: control, group [2]: Serotonin, group [3]: diabetic, and group [4]: Serotonin-diabetic. The rats were weighed and serum levels of glucose, insulin, malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, serotonin, thyroid stimulating hormone, thyroxine, and triiodothyronine were measured. Our results presented that there was a significant increase in T3, T4, glucose, and MDA in the diabetic group compared to the control, while a significant decrease in T3, and T4, glucose, and MDA in the Serotonin with diabetic group compared to diabetic group. Furthermore, a significant decrease in TSH, serotonin, insulin and GPX, CAT, and SOD antioxidants in the diabetic group compared to control, while a significant increase in serum TSH, serotonin, insulin and CAT, GPX and SOD antioxidants in the Serotonin+diabetic group compared to diabetic group as well as a significant increase in serum insulin in the Serotonin group compared to all other groups. Serotonin plays a protective role against diabetes-induced and pituitary-thyroid disorder caused by diabetes which might be because of its antioxidant qualities and ability to maintain glucose and insulin balance. https://journal.uokufa.edu.iq/index.php/kjvs/article/view/12699Anti-oxidantsDiabetes MellitusOxidative stressPituitary-thyroidSerotonin |
| spellingShingle | Sumayah Faruq Kasim Fouad Ziedan Hamzah Role of serotonin on pituitary-thyroid functions and antioxidants in diabetic male rats Kufa Journal for Veterinary Medical Sciences Anti-oxidants Diabetes Mellitus Oxidative stress Pituitary-thyroid Serotonin |
| title | Role of serotonin on pituitary-thyroid functions and antioxidants in diabetic male rats |
| title_full | Role of serotonin on pituitary-thyroid functions and antioxidants in diabetic male rats |
| title_fullStr | Role of serotonin on pituitary-thyroid functions and antioxidants in diabetic male rats |
| title_full_unstemmed | Role of serotonin on pituitary-thyroid functions and antioxidants in diabetic male rats |
| title_short | Role of serotonin on pituitary-thyroid functions and antioxidants in diabetic male rats |
| title_sort | role of serotonin on pituitary thyroid functions and antioxidants in diabetic male rats |
| topic | Anti-oxidants Diabetes Mellitus Oxidative stress Pituitary-thyroid Serotonin |
| url | https://journal.uokufa.edu.iq/index.php/kjvs/article/view/12699 |
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