Ion Channels as Potential Tools for the Diagnosis, Prognosis, and Treatment of HPV-Associated Cancers
The human papilloma virus (HPV) group comprises approximately 200 genetic types that have a special affinity for epithelial tissues and can vary from producing benign symptoms to developing into complicated pathologies, such as cancer. The HPV replicative cycle affects various cellular and molecular...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Online Access: | https://www.mdpi.com/2073-4409/12/10/1376 |
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| author | Andrea Jazmín Chiliquinga Brenda Acosta Ingrid Ogonaga-Borja Fernanda Villarruel-Melquiades Jaime de la Garza Patricio Gariglio Rodolfo Ocádiz-Delgado Ana Ramírez Yesennia Sánchez-Pérez Claudia M. García-Cuellar Cecilia Bañuelos Javier Camacho |
| author_facet | Andrea Jazmín Chiliquinga Brenda Acosta Ingrid Ogonaga-Borja Fernanda Villarruel-Melquiades Jaime de la Garza Patricio Gariglio Rodolfo Ocádiz-Delgado Ana Ramírez Yesennia Sánchez-Pérez Claudia M. García-Cuellar Cecilia Bañuelos Javier Camacho |
| author_sort | Andrea Jazmín Chiliquinga |
| collection | DOAJ |
| description | The human papilloma virus (HPV) group comprises approximately 200 genetic types that have a special affinity for epithelial tissues and can vary from producing benign symptoms to developing into complicated pathologies, such as cancer. The HPV replicative cycle affects various cellular and molecular processes, including DNA insertions and methylation and relevant pathways related to pRb and p53, as well as ion channel expression or function. Ion channels are responsible for the flow of ions across cell membranes and play very important roles in human physiology, including the regulation of ion homeostasis, electrical excitability, and cell signaling. However, when ion channel function or expression is altered, the channels can trigger a wide range of channelopathies, including cancer. In consequence, the up- or down-regulation of ion channels in cancer makes them attractive molecular markers for the diagnosis, prognosis, and treatment of the disease. Interestingly, the activity or expression of several ion channels is dysregulated in HPV-associated cancers. Here, we review the status of ion channels and their regulation in HPV-associated cancers and discuss the potential molecular mechanisms involved. Understanding the dynamics of ion channels in these cancers should help to improve early diagnosis, prognosis, and treatment in the benefit of HPV-associated cancer patients. |
| first_indexed | 2024-03-11T03:51:20Z |
| format | Article |
| id | doaj.art-06cfc6c11d6e4b9ea13913a8eda4beb5 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T03:51:20Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-06cfc6c11d6e4b9ea13913a8eda4beb52023-11-18T00:52:42ZengMDPI AGCells2073-44092023-05-011210137610.3390/cells12101376Ion Channels as Potential Tools for the Diagnosis, Prognosis, and Treatment of HPV-Associated CancersAndrea Jazmín Chiliquinga0Brenda Acosta1Ingrid Ogonaga-Borja2Fernanda Villarruel-Melquiades3Jaime de la Garza4Patricio Gariglio5Rodolfo Ocádiz-Delgado6Ana Ramírez7Yesennia Sánchez-Pérez8Claudia M. García-Cuellar9Cecilia Bañuelos10Javier Camacho11Grupo de Investigación de Ciencias en Red, Universidad Técnica del Norte, Ibarra 100105, EcuadorGrupo de Investigación de Ciencias en Red, Universidad Técnica del Norte, Ibarra 100105, EcuadorGrupo de Investigación de Ciencias en Red, Universidad Técnica del Norte, Ibarra 100105, EcuadorDepartamento de Farmacología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Ciudad de Mexico CP 07360, MexicoUnidad de Oncología Torácica y Laboratorio de Medicina Personalizada, Instituto Nacional de Cancerología (INCan), Tlalpan, Ciudad de Mexico CP 14080, MexicoDepartamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Ciudad de Mexico CP 07360, MexicoDepartamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Ciudad de Mexico CP 07360, MexicoFacultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, Calzada Universidad 14418, Tijuana 22390, MexicoSubdirección de Investigación Básica, Instituto Nacional de Cancerología (INCan), Tlalpan, Ciudad de Mexico CP 14080, MexicoSubdirección de Investigación Básica, Instituto Nacional de Cancerología (INCan), Tlalpan, Ciudad de Mexico CP 14080, MexicoPrograma Transdisciplinario en Desarrollo Científico y Tecnológico para la Sociedad, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Ciudad de Mexico CP 07360, MexicoDepartamento de Farmacología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Ciudad de Mexico CP 07360, MexicoThe human papilloma virus (HPV) group comprises approximately 200 genetic types that have a special affinity for epithelial tissues and can vary from producing benign symptoms to developing into complicated pathologies, such as cancer. The HPV replicative cycle affects various cellular and molecular processes, including DNA insertions and methylation and relevant pathways related to pRb and p53, as well as ion channel expression or function. Ion channels are responsible for the flow of ions across cell membranes and play very important roles in human physiology, including the regulation of ion homeostasis, electrical excitability, and cell signaling. However, when ion channel function or expression is altered, the channels can trigger a wide range of channelopathies, including cancer. In consequence, the up- or down-regulation of ion channels in cancer makes them attractive molecular markers for the diagnosis, prognosis, and treatment of the disease. Interestingly, the activity or expression of several ion channels is dysregulated in HPV-associated cancers. Here, we review the status of ion channels and their regulation in HPV-associated cancers and discuss the potential molecular mechanisms involved. Understanding the dynamics of ion channels in these cancers should help to improve early diagnosis, prognosis, and treatment in the benefit of HPV-associated cancer patients.https://www.mdpi.com/2073-4409/12/10/1376HPVcancerion channelsmolecular markers |
| spellingShingle | Andrea Jazmín Chiliquinga Brenda Acosta Ingrid Ogonaga-Borja Fernanda Villarruel-Melquiades Jaime de la Garza Patricio Gariglio Rodolfo Ocádiz-Delgado Ana Ramírez Yesennia Sánchez-Pérez Claudia M. García-Cuellar Cecilia Bañuelos Javier Camacho Ion Channels as Potential Tools for the Diagnosis, Prognosis, and Treatment of HPV-Associated Cancers Cells HPV cancer ion channels molecular markers |
| title | Ion Channels as Potential Tools for the Diagnosis, Prognosis, and Treatment of HPV-Associated Cancers |
| title_full | Ion Channels as Potential Tools for the Diagnosis, Prognosis, and Treatment of HPV-Associated Cancers |
| title_fullStr | Ion Channels as Potential Tools for the Diagnosis, Prognosis, and Treatment of HPV-Associated Cancers |
| title_full_unstemmed | Ion Channels as Potential Tools for the Diagnosis, Prognosis, and Treatment of HPV-Associated Cancers |
| title_short | Ion Channels as Potential Tools for the Diagnosis, Prognosis, and Treatment of HPV-Associated Cancers |
| title_sort | ion channels as potential tools for the diagnosis prognosis and treatment of hpv associated cancers |
| topic | HPV cancer ion channels molecular markers |
| url | https://www.mdpi.com/2073-4409/12/10/1376 |
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