Identifying risk factors for cutaneous disease among solid organ transplant recipients: A retrospective reviewCapsule Summary
Background: As solid organ transplant recipient (SOTR) life expectancy lengthens, the risk of developing other chronic diseases also increases. Objective: To determine the cutaneous pathologies for which SOTRs are at an increased risk. Methods: We performed a retrospective review of SOTRs seen by de...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | JAAD International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666328723000305 |
| _version_ | 1827946247021920256 |
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| author | Chelsea Shope, MSCR Laura Andrews, MSCR Mary Nan Leath, BS Courtney Linkous, BA Lara Wine Lee, MD, PhD |
| author_facet | Chelsea Shope, MSCR Laura Andrews, MSCR Mary Nan Leath, BS Courtney Linkous, BA Lara Wine Lee, MD, PhD |
| author_sort | Chelsea Shope, MSCR |
| collection | DOAJ |
| description | Background: As solid organ transplant recipient (SOTR) life expectancy lengthens, the risk of developing other chronic diseases also increases. Objective: To determine the cutaneous pathologies for which SOTRs are at an increased risk. Methods: We performed a retrospective review of SOTRs seen by dermatology from January 1, 2012 and June 1, 2022. Data were analyzed using multivariate logistic regression. Benjamini Hochberg-adjusted P values were examined for multiplicity. Results: Five hundred and thirty SOTRs were identified. Patients had cutaneous malignancy (38.3%), precancerous lesions (32.5%), inflammatory (35.5%), and infectious diseases (33.1%). Odds of precancerous lesions were higher with increased age at transplant (odds ratio [OR], 1.04; adjusted P =.006), and lower with female sex (OR, 0.505; adjusted P =.006) and African American race (OR, 0.027; adjusted P =.006). Odds of inflammatory lesions were lower with increased age at transplant (OR, 0.979; adjusted P =.023). Odds of infectious diseases were higher with prednisone use (OR, 2.615; adjusted P value =.023). Limitations: This study is retrospective and was not able to capture patients seen by dermatology outside of our institution. Conclusions: SOTRs at risk of cutaneous lesions should be referred to dermatology because these conditions may place a significant burden on the quality of life. |
| first_indexed | 2024-03-13T10:55:56Z |
| format | Article |
| id | doaj.art-06d16e415bb94c61bc8932fc8aad2591 |
| institution | Directory Open Access Journal |
| issn | 2666-3287 |
| language | English |
| last_indexed | 2024-03-13T10:55:56Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JAAD International |
| spelling | doaj.art-06d16e415bb94c61bc8932fc8aad25912023-05-17T04:23:27ZengElsevierJAAD International2666-32872023-06-0111157164Identifying risk factors for cutaneous disease among solid organ transplant recipients: A retrospective reviewCapsule SummaryChelsea Shope, MSCR0Laura Andrews, MSCR1Mary Nan Leath, BS2Courtney Linkous, BA3Lara Wine Lee, MD, PhD4College of Medicine, Medical University of South Carolina, Charleston, South Carolina; Correspondence: Chelsea Shope, MSCR, College of Medicine, Medical University of South Carolina, 135 Rutledge Ave., 11th Floor Charleston, SC 29425.College of Medicine, Medical University of South Carolina, Charleston, South CarolinaCollege of Medicine, Medical University of South Carolina, Charleston, South CarolinaCollege of Medicine, Medical University of South Carolina, Charleston, South CarolinaDepartment of Dermatology, Medical University of South Carolina, Charleston, South CarolinaBackground: As solid organ transplant recipient (SOTR) life expectancy lengthens, the risk of developing other chronic diseases also increases. Objective: To determine the cutaneous pathologies for which SOTRs are at an increased risk. Methods: We performed a retrospective review of SOTRs seen by dermatology from January 1, 2012 and June 1, 2022. Data were analyzed using multivariate logistic regression. Benjamini Hochberg-adjusted P values were examined for multiplicity. Results: Five hundred and thirty SOTRs were identified. Patients had cutaneous malignancy (38.3%), precancerous lesions (32.5%), inflammatory (35.5%), and infectious diseases (33.1%). Odds of precancerous lesions were higher with increased age at transplant (odds ratio [OR], 1.04; adjusted P =.006), and lower with female sex (OR, 0.505; adjusted P =.006) and African American race (OR, 0.027; adjusted P =.006). Odds of inflammatory lesions were lower with increased age at transplant (OR, 0.979; adjusted P =.023). Odds of infectious diseases were higher with prednisone use (OR, 2.615; adjusted P value =.023). Limitations: This study is retrospective and was not able to capture patients seen by dermatology outside of our institution. Conclusions: SOTRs at risk of cutaneous lesions should be referred to dermatology because these conditions may place a significant burden on the quality of life.http://www.sciencedirect.com/science/article/pii/S2666328723000305immunosuppressioninflammatoryinfectiousorgan transplantprecancer |
| spellingShingle | Chelsea Shope, MSCR Laura Andrews, MSCR Mary Nan Leath, BS Courtney Linkous, BA Lara Wine Lee, MD, PhD Identifying risk factors for cutaneous disease among solid organ transplant recipients: A retrospective reviewCapsule Summary JAAD International immunosuppression inflammatory infectious organ transplant precancer |
| title | Identifying risk factors for cutaneous disease among solid organ transplant recipients: A retrospective reviewCapsule Summary |
| title_full | Identifying risk factors for cutaneous disease among solid organ transplant recipients: A retrospective reviewCapsule Summary |
| title_fullStr | Identifying risk factors for cutaneous disease among solid organ transplant recipients: A retrospective reviewCapsule Summary |
| title_full_unstemmed | Identifying risk factors for cutaneous disease among solid organ transplant recipients: A retrospective reviewCapsule Summary |
| title_short | Identifying risk factors for cutaneous disease among solid organ transplant recipients: A retrospective reviewCapsule Summary |
| title_sort | identifying risk factors for cutaneous disease among solid organ transplant recipients a retrospective reviewcapsule summary |
| topic | immunosuppression inflammatory infectious organ transplant precancer |
| url | http://www.sciencedirect.com/science/article/pii/S2666328723000305 |
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