Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis

Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis

Cellular differentiation is associated with dynamic chromatin remodeling in establishing a cell-type-specific epigenomic landscape. Here, we find that mouse testis-specific and replication-dependent histone H3 variant H3t is essential for very early stages of spermatogenesis. H3t gene deficiency lea...

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Bibliographic Details
Main Authors: Jun Ueda, Akihito Harada, Takashi Urahama, Shinichi Machida, Kazumitsu Maehara, Masashi Hada, Yoshinori Makino, Jumpei Nogami, Naoki Horikoshi, Akihisa Osakabe, Hiroyuki Taguchi, Hiroki Tanaka, Hiroaki Tachiwana, Tatsuma Yao, Minami Yamada, Takashi Iwamoto, Ayako Isotani, Masahito Ikawa, Taro Tachibana, Yuki Okada, Hiroshi Kimura, Yasuyuki Ohkawa, Hitoshi Kurumizaka, Kazuo Yamagata
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
histone variant
spermatogenesis
nucleosome
chromatin
crystal structure
epigenetics
testes
meiosis
spermatogonial differentiation
spermatozoa
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716317727

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