Ancient duplication, coevolution, and selection at the MHC class IIA and IIB genes of birds

Ancient duplication, coevolution, and selection at the MHC class IIA and IIB genes of birds

IntroductionThe Major Histocompatibility Complex (MHC) of vertebrates is a dynamically evolving multigene family primarily responsible for recognizing non-self peptide antigens and triggering a pathogen-specific adaptive immune response. In birds, the MHC was previously thought to evolve via concert...

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Bibliographic Details
Main Authors: Piotr Minias, Scott V. Edwards, Wiesław Babik
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
birds
duplication
concerted evolution
major histocompatibility complex
MHC
orthology
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1250824/full

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