AQP5 complements LGR5 to determine the fates of gastric cancer stem cells through regulating ULK1 ubiquitination

AQP5 complements LGR5 to determine the fates of gastric cancer stem cells through regulating ULK1 ubiquitination

Abstract Background Cancer stem cells (CSCs) are regarded as the "seed cells" for tumorigenesis, metastasis, recurrence and drug resistance. However, specific surface markers of CSCs of different origins have not been documented. Methods Single-cell sequencing was used to analyze the highl...

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Bibliographic Details
Main Authors: Rou Zhao, Baoyu He, Qingli Bie, Jinghe Cao, Haoran Lu, Zhixin Zhang, Jing Liang, Li Wei, Huabao Xiong, Bin Zhang
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cancer stem cells
AQP5
LGR5
Autophagy
ULK1
Gastric cancer
Online Access:https://doi.org/10.1186/s13046-022-02532-w

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