Infections and systemic lupus erythematosus
ABSTRACT Objective To determine the incidence of infections in a population of systemic lupus erythematosus individuals and the characteristics of infections regarding original site, as well as to study the possible associations between infections and treatment. Methods An analytical retrospecti...
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| Format: | Article |
| Language: | English |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
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| Series: | Einstein (São Paulo) |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082016000100047&lng=en&tlng=en |
| _version_ | 1818411198787354624 |
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| author | Thelma Larocca Skare Jéssica Scherer Dagostini Patricia Imai Zanardi Renato Mitsunori Nisihara |
| author_facet | Thelma Larocca Skare Jéssica Scherer Dagostini Patricia Imai Zanardi Renato Mitsunori Nisihara |
| author_sort | Thelma Larocca Skare |
| collection | DOAJ |
| description | ABSTRACT Objective To determine the incidence of infections in a population of systemic lupus erythematosus individuals and the characteristics of infections regarding original site, as well as to study the possible associations between infections and treatment. Methods An analytical retrospective study using data from medical charts of systemic lupus erythematosus patients from a single university hospital. A total of 144 patients followed up for five years were included. Data collected comprised age of patients and age at onset of lupus, sex and ethnicity, disease duration before the study period, medications, cumulative dose of prednisone, occurrence of infections and their original site. Results The most frequent infections were urinary tract infections (correlated to use of prednisone − p<0.0001 and cyclophosphamide − p=0.045), upper airways infections (correlated to use of prednisone − p=0.0004, mycophenolate mofetil − p=0.0005, and cyclosporine − p=0.025), and pneumonia (associated to prednisone − p=0.017). Conclusion Prednisone was the drug more often associated with presence of infections, pointing to the need for a more judicious management of this drug. |
| first_indexed | 2024-12-14T10:27:36Z |
| format | Article |
| id | doaj.art-06d2e60f133e4f48bd4f7a10f7b1fb81 |
| institution | Directory Open Access Journal |
| issn | 2317-6385 |
| language | English |
| last_indexed | 2024-12-14T10:27:36Z |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-06d2e60f133e4f48bd4f7a10f7b1fb812022-12-21T23:06:15ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-6385141475110.1590/S1679-45082016AO3490S1679-45082016000100047Infections and systemic lupus erythematosusThelma Larocca SkareJéssica Scherer DagostiniPatricia Imai ZanardiRenato Mitsunori NisiharaABSTRACT Objective To determine the incidence of infections in a population of systemic lupus erythematosus individuals and the characteristics of infections regarding original site, as well as to study the possible associations between infections and treatment. Methods An analytical retrospective study using data from medical charts of systemic lupus erythematosus patients from a single university hospital. A total of 144 patients followed up for five years were included. Data collected comprised age of patients and age at onset of lupus, sex and ethnicity, disease duration before the study period, medications, cumulative dose of prednisone, occurrence of infections and their original site. Results The most frequent infections were urinary tract infections (correlated to use of prednisone − p<0.0001 and cyclophosphamide − p=0.045), upper airways infections (correlated to use of prednisone − p=0.0004, mycophenolate mofetil − p=0.0005, and cyclosporine − p=0.025), and pneumonia (associated to prednisone − p=0.017). Conclusion Prednisone was the drug more often associated with presence of infections, pointing to the need for a more judicious management of this drug.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082016000100047&lng=en&tlng=enLúpus eritematoso sistêmico/complicaçõesInfecções urinárias/etiologiaImunossupressão |
| spellingShingle | Thelma Larocca Skare Jéssica Scherer Dagostini Patricia Imai Zanardi Renato Mitsunori Nisihara Infections and systemic lupus erythematosus Einstein (São Paulo) Lúpus eritematoso sistêmico/complicações Infecções urinárias/etiologia Imunossupressão |
| title | Infections and systemic lupus erythematosus |
| title_full | Infections and systemic lupus erythematosus |
| title_fullStr | Infections and systemic lupus erythematosus |
| title_full_unstemmed | Infections and systemic lupus erythematosus |
| title_short | Infections and systemic lupus erythematosus |
| title_sort | infections and systemic lupus erythematosus |
| topic | Lúpus eritematoso sistêmico/complicações Infecções urinárias/etiologia Imunossupressão |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082016000100047&lng=en&tlng=en |
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