Effect of magnesium sulfate nebulization on the incidence of postoperative sore throat
Background: Postoperative sore throat (POST) is a well-recognized complication after general anesthesia (GA). Numerous nonpharmacological and pharmacological measures have been used for attenuating POST with variable success. Aims and Objectives: The present study was conducted to compare the effici...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Journal of Anaesthesiology Clinical Pharmacology |
| Subjects: | |
| Online Access: | http://www.joacp.org/article.asp?issn=0970-9185;year=2016;volume=32;issue=2;spage=168;epage=171;aulast=Yadav |
| _version_ | 1819113745851351040 |
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| author | Monu Yadav Nitish Chalumuru Ramachandran Gopinath |
| author_facet | Monu Yadav Nitish Chalumuru Ramachandran Gopinath |
| author_sort | Monu Yadav |
| collection | DOAJ |
| description | Background: Postoperative sore throat (POST) is a well-recognized complication after general anesthesia (GA). Numerous nonpharmacological and pharmacological measures have been used for attenuating POST with variable success.
Aims and Objectives: The present study was conducted to compare the efficiency of preoperative nebulization of normal saline and magnesium sulfate in reducing the incidence of POST following GA.
Materials and Methods: Following institutional ethical committee approval and written informed consent, a prospective randomized double-blinded study was conducted in 100 cases divided into two equal groups. Patients included in the study were of either gender belonging to American Society of Anesthesiologist (ASA) status 1 or 2 undergoing elective surgery of approximately 2 h or more duration requiring tracheal intubation. Patients in Group A are nebulized with 3 ml of normal saline and the patients in Group B are nebulized with 3 ml of 225 mg isotonic nebulized magnesium sulfate for 15 min, 5 min before induction of anesthesia. The incidence of POST at rest and on swallowing and any undue complaints at 0, 2, 4, and 24 h in the postoperative period are evaluated.
Results: There is no significant difference in POST at rest during 0th, 2nd and 4th h between normal saline and MgSO4. Significant difference is seen at 24th h, where MgSO4lessens POST. There is no significant difference in POST “on swallowing” during 0th and 2nd h between normal saline and MgSO4. Significant difference is seen at 4th h, where MgSO4has been shown to lessen POST.
Conclusions: MgSO4significantly reduces the incidence of POST compared to normal saline. |
| first_indexed | 2024-12-22T04:34:18Z |
| format | Article |
| id | doaj.art-06d578d037aa42d98f096222b6deee7a |
| institution | Directory Open Access Journal |
| issn | 0970-9185 |
| language | English |
| last_indexed | 2024-12-22T04:34:18Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Anaesthesiology Clinical Pharmacology |
| spelling | doaj.art-06d578d037aa42d98f096222b6deee7a2022-12-21T18:38:55ZengWolters Kluwer Medknow PublicationsJournal of Anaesthesiology Clinical Pharmacology0970-91852016-01-0132216817110.4103/0970-9185.173367Effect of magnesium sulfate nebulization on the incidence of postoperative sore throatMonu YadavNitish ChalumuruRamachandran GopinathBackground: Postoperative sore throat (POST) is a well-recognized complication after general anesthesia (GA). Numerous nonpharmacological and pharmacological measures have been used for attenuating POST with variable success. Aims and Objectives: The present study was conducted to compare the efficiency of preoperative nebulization of normal saline and magnesium sulfate in reducing the incidence of POST following GA. Materials and Methods: Following institutional ethical committee approval and written informed consent, a prospective randomized double-blinded study was conducted in 100 cases divided into two equal groups. Patients included in the study were of either gender belonging to American Society of Anesthesiologist (ASA) status 1 or 2 undergoing elective surgery of approximately 2 h or more duration requiring tracheal intubation. Patients in Group A are nebulized with 3 ml of normal saline and the patients in Group B are nebulized with 3 ml of 225 mg isotonic nebulized magnesium sulfate for 15 min, 5 min before induction of anesthesia. The incidence of POST at rest and on swallowing and any undue complaints at 0, 2, 4, and 24 h in the postoperative period are evaluated. Results: There is no significant difference in POST at rest during 0th, 2nd and 4th h between normal saline and MgSO4. Significant difference is seen at 24th h, where MgSO4lessens POST. There is no significant difference in POST “on swallowing” during 0th and 2nd h between normal saline and MgSO4. Significant difference is seen at 4th h, where MgSO4has been shown to lessen POST. Conclusions: MgSO4significantly reduces the incidence of POST compared to normal saline.http://www.joacp.org/article.asp?issn=0970-9185;year=2016;volume=32;issue=2;spage=168;epage=171;aulast=YadavIntratracheal intubation, magnesium sulfate, pharyngitis |
| spellingShingle | Monu Yadav Nitish Chalumuru Ramachandran Gopinath Effect of magnesium sulfate nebulization on the incidence of postoperative sore throat Journal of Anaesthesiology Clinical Pharmacology Intratracheal intubation, magnesium sulfate, pharyngitis |
| title | Effect of magnesium sulfate nebulization on the incidence of postoperative sore throat |
| title_full | Effect of magnesium sulfate nebulization on the incidence of postoperative sore throat |
| title_fullStr | Effect of magnesium sulfate nebulization on the incidence of postoperative sore throat |
| title_full_unstemmed | Effect of magnesium sulfate nebulization on the incidence of postoperative sore throat |
| title_short | Effect of magnesium sulfate nebulization on the incidence of postoperative sore throat |
| title_sort | effect of magnesium sulfate nebulization on the incidence of postoperative sore throat |
| topic | Intratracheal intubation, magnesium sulfate, pharyngitis |
| url | http://www.joacp.org/article.asp?issn=0970-9185;year=2016;volume=32;issue=2;spage=168;epage=171;aulast=Yadav |
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