LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein

LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein

<p>Abstract</p> <p>Background</p> <p>Human Immunodeficiency Virus-1 (HIV-1) associated neurocognitive disorders (HANDs) are accompanied by significant morbidity, which persists despite the use of combined antiretroviral therapy (cART). While activated microglia play a r...

Full description

Bibliographic Details
Main Authors: Marker Daniel F, Puccini Jenna M, Mockus Taryn E, Barbieri Justin, Lu Shao-Ming, Gelbard Harris A
Format: Article
Language:English
Published: BMC 2012-11-01
Series:Journal of Neuroinflammation
Subjects:
Phagocytosis
Microglia
HIV-1
Tat
Leucine-rich repeat kinase 2 (LRRK2)
AnnexinV
Parkinson’s disease
Brain-specific angiogenesis inhibitor 1 (BAI1)
Online Access:http://www.jneuroinflammation.com/content/9/1/261

Internet

http://www.jneuroinflammation.com/content/9/1/261

Similar Items