Health-related quality of life in patients with Chagas disease: a review of the evidence
Chagas disease (ChD), a neglected tropical disease caused by infection with the parasite Trypanosoma cruzi (T. cruzi), remains a serious public health issue in Latin America and is an emerging disease in several non-endemic countries, where knowledge of the condition and experience with its clinical...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2015-04-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000200121&lng=en&tlng=en |
| _version_ | 1818534839784046592 |
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| author | Giovane Rodrigo Sousa Henrique Silveira Costa Aline Cristina Souza Maria Carmo Pereira Nunes Márcia Maria Oliveira Lima Manoel Otávio da Costa Rocha |
| author_facet | Giovane Rodrigo Sousa Henrique Silveira Costa Aline Cristina Souza Maria Carmo Pereira Nunes Márcia Maria Oliveira Lima Manoel Otávio da Costa Rocha |
| author_sort | Giovane Rodrigo Sousa |
| collection | DOAJ |
| description | Chagas disease (ChD), a neglected tropical disease caused by infection with the parasite Trypanosoma cruzi (T. cruzi), remains a serious public health issue in Latin America and is an emerging disease in several non-endemic countries, where knowledge of the condition and experience with its clinical management are limited. Regionally, the disease is the major cause of disability secondary to tropical diseases in young adults. Health-related quality of life (HRQoL) impairment is common in patients with ChD, especially in those with Chagas dilated cardiomyopathy, the most severe manifestation of the disease, which frequently leads to heart failure. The aim of this review was to conduct a literature search for studies that have evaluated the determining factors of HRQoL in ChD patients. We included cross-sectional, case-control, cohort, and experimental studies, as well as clinical trials that evaluated the HRQoL in ChD patients aged 18 to 60 years and are presenting an explicit description of statistical analysis. Using a combination of keywords based on Descriptors in Health Sciences (DeCS) and Medical Subject Headings (MeSH) for searches in PubMed and the Scientific Electronic Library Online (SciELO), 148 studies were found. After exclusions, 12 studies were selected for analysis. Three main findings were extracted from these studies: 1) cardiac involvement is associated with a worse HRQoL in ChD patients; 2) HRQoL is associated with the patients' functional capacity; and 3) simple and inexpensive therapeutic measures are effective for improving HRQoL in ChD patients. Hence, ChD patients' functional capacity, the effectiveness of non-surgical conservative treatment, and cardiac involvement are important determining factors for the HRQoL in ChD patients. |
| first_indexed | 2024-12-11T18:16:49Z |
| format | Article |
| id | doaj.art-06d6aa5a0c2a410ab8183a946c666c8d |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-12-11T18:16:49Z |
| publishDate | 2015-04-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-06d6aa5a0c2a410ab8183a946c666c8d2022-12-22T00:55:24ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492015-04-0148212112810.1590/0037-8682-0244-2014S0037-86822015000200121Health-related quality of life in patients with Chagas disease: a review of the evidenceGiovane Rodrigo SousaHenrique Silveira CostaAline Cristina SouzaMaria Carmo Pereira NunesMárcia Maria Oliveira LimaManoel Otávio da Costa RochaChagas disease (ChD), a neglected tropical disease caused by infection with the parasite Trypanosoma cruzi (T. cruzi), remains a serious public health issue in Latin America and is an emerging disease in several non-endemic countries, where knowledge of the condition and experience with its clinical management are limited. Regionally, the disease is the major cause of disability secondary to tropical diseases in young adults. Health-related quality of life (HRQoL) impairment is common in patients with ChD, especially in those with Chagas dilated cardiomyopathy, the most severe manifestation of the disease, which frequently leads to heart failure. The aim of this review was to conduct a literature search for studies that have evaluated the determining factors of HRQoL in ChD patients. We included cross-sectional, case-control, cohort, and experimental studies, as well as clinical trials that evaluated the HRQoL in ChD patients aged 18 to 60 years and are presenting an explicit description of statistical analysis. Using a combination of keywords based on Descriptors in Health Sciences (DeCS) and Medical Subject Headings (MeSH) for searches in PubMed and the Scientific Electronic Library Online (SciELO), 148 studies were found. After exclusions, 12 studies were selected for analysis. Three main findings were extracted from these studies: 1) cardiac involvement is associated with a worse HRQoL in ChD patients; 2) HRQoL is associated with the patients' functional capacity; and 3) simple and inexpensive therapeutic measures are effective for improving HRQoL in ChD patients. Hence, ChD patients' functional capacity, the effectiveness of non-surgical conservative treatment, and cardiac involvement are important determining factors for the HRQoL in ChD patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000200121&lng=en&tlng=enChagas diseaseQuality of lifeHealth-related quality of lifeCardiomyopathyDetermining factors |
| spellingShingle | Giovane Rodrigo Sousa Henrique Silveira Costa Aline Cristina Souza Maria Carmo Pereira Nunes Márcia Maria Oliveira Lima Manoel Otávio da Costa Rocha Health-related quality of life in patients with Chagas disease: a review of the evidence Revista da Sociedade Brasileira de Medicina Tropical Chagas disease Quality of life Health-related quality of life Cardiomyopathy Determining factors |
| title | Health-related quality of life in patients with Chagas disease: a review of the evidence |
| title_full | Health-related quality of life in patients with Chagas disease: a review of the evidence |
| title_fullStr | Health-related quality of life in patients with Chagas disease: a review of the evidence |
| title_full_unstemmed | Health-related quality of life in patients with Chagas disease: a review of the evidence |
| title_short | Health-related quality of life in patients with Chagas disease: a review of the evidence |
| title_sort | health related quality of life in patients with chagas disease a review of the evidence |
| topic | Chagas disease Quality of life Health-related quality of life Cardiomyopathy Determining factors |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000200121&lng=en&tlng=en |
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