The Role of Mitochondrial Dysfunction in Atrial Fibrillation: Translation to Druggable Target and Biomarker Discovery
Atrial fibrillation (AF) is the most prevalent and progressive cardiac arrhythmia worldwide and is associated with serious complications such as heart failure and ischemic stroke. Current treatment modalities attenuate AF symptoms and are only moderately effective in halting the arrhythmia. Therefor...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/16/8463 |
| _version_ | 1797523609860702208 |
|---|---|
| author | Lisa Pool Leonoor F. J. M. Wijdeveld Natasja M. S. de Groot Bianca J. J. M. Brundel |
| author_facet | Lisa Pool Leonoor F. J. M. Wijdeveld Natasja M. S. de Groot Bianca J. J. M. Brundel |
| author_sort | Lisa Pool |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is the most prevalent and progressive cardiac arrhythmia worldwide and is associated with serious complications such as heart failure and ischemic stroke. Current treatment modalities attenuate AF symptoms and are only moderately effective in halting the arrhythmia. Therefore, there is an urgent need to dissect molecular mechanisms that drive AF. As AF is characterized by a rapid atrial activation rate, which requires a high energy metabolism, a role of mitochondrial dysfunction in AF pathophysiology is plausible. It is well known that mitochondria play a central role in cardiomyocyte function, as they produce energy to support the mechanical and electrical function of the heart. Details on the molecular mechanisms underlying mitochondrial dysfunction are increasingly being uncovered as a contributing factor in the loss of cardiomyocyte function and AF. Considering the high prevalence of AF, investigating the role of mitochondrial impairment in AF may guide the path towards new therapeutic and diagnostic targets. In this review, the latest evidence on the role of mitochondria dysfunction in AF is presented. We highlight the key modulators of mitochondrial dysfunction that drive AF and discuss whether they represent potential targets for therapeutic interventions and diagnostics in clinical AF. |
| first_indexed | 2024-03-10T08:45:27Z |
| format | Article |
| id | doaj.art-06d9169de9864094a85d581a8783c54b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:45:27Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-06d9169de9864094a85d581a8783c54b2023-11-22T07:55:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012216846310.3390/ijms22168463The Role of Mitochondrial Dysfunction in Atrial Fibrillation: Translation to Druggable Target and Biomarker DiscoveryLisa Pool0Leonoor F. J. M. Wijdeveld1Natasja M. S. de Groot2Bianca J. J. M. Brundel3Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The NetherlandsDepartment of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The NetherlandsErasmus Medical Center, Department of Cardiology, 3015 GD Rotterdam, The NetherlandsDepartment of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The NetherlandsAtrial fibrillation (AF) is the most prevalent and progressive cardiac arrhythmia worldwide and is associated with serious complications such as heart failure and ischemic stroke. Current treatment modalities attenuate AF symptoms and are only moderately effective in halting the arrhythmia. Therefore, there is an urgent need to dissect molecular mechanisms that drive AF. As AF is characterized by a rapid atrial activation rate, which requires a high energy metabolism, a role of mitochondrial dysfunction in AF pathophysiology is plausible. It is well known that mitochondria play a central role in cardiomyocyte function, as they produce energy to support the mechanical and electrical function of the heart. Details on the molecular mechanisms underlying mitochondrial dysfunction are increasingly being uncovered as a contributing factor in the loss of cardiomyocyte function and AF. Considering the high prevalence of AF, investigating the role of mitochondrial impairment in AF may guide the path towards new therapeutic and diagnostic targets. In this review, the latest evidence on the role of mitochondria dysfunction in AF is presented. We highlight the key modulators of mitochondrial dysfunction that drive AF and discuss whether they represent potential targets for therapeutic interventions and diagnostics in clinical AF.https://www.mdpi.com/1422-0067/22/16/8463atrial fibrillationmitochondriaelectrophysiologyatrial cardiomyopathydiagnosticsbiomarker |
| spellingShingle | Lisa Pool Leonoor F. J. M. Wijdeveld Natasja M. S. de Groot Bianca J. J. M. Brundel The Role of Mitochondrial Dysfunction in Atrial Fibrillation: Translation to Druggable Target and Biomarker Discovery International Journal of Molecular Sciences atrial fibrillation mitochondria electrophysiology atrial cardiomyopathy diagnostics biomarker |
| title | The Role of Mitochondrial Dysfunction in Atrial Fibrillation: Translation to Druggable Target and Biomarker Discovery |
| title_full | The Role of Mitochondrial Dysfunction in Atrial Fibrillation: Translation to Druggable Target and Biomarker Discovery |
| title_fullStr | The Role of Mitochondrial Dysfunction in Atrial Fibrillation: Translation to Druggable Target and Biomarker Discovery |
| title_full_unstemmed | The Role of Mitochondrial Dysfunction in Atrial Fibrillation: Translation to Druggable Target and Biomarker Discovery |
| title_short | The Role of Mitochondrial Dysfunction in Atrial Fibrillation: Translation to Druggable Target and Biomarker Discovery |
| title_sort | role of mitochondrial dysfunction in atrial fibrillation translation to druggable target and biomarker discovery |
| topic | atrial fibrillation mitochondria electrophysiology atrial cardiomyopathy diagnostics biomarker |
| url | https://www.mdpi.com/1422-0067/22/16/8463 |
| work_keys_str_mv | AT lisapool theroleofmitochondrialdysfunctioninatrialfibrillationtranslationtodruggabletargetandbiomarkerdiscovery AT leonoorfjmwijdeveld theroleofmitochondrialdysfunctioninatrialfibrillationtranslationtodruggabletargetandbiomarkerdiscovery AT natasjamsdegroot theroleofmitochondrialdysfunctioninatrialfibrillationtranslationtodruggabletargetandbiomarkerdiscovery AT biancajjmbrundel theroleofmitochondrialdysfunctioninatrialfibrillationtranslationtodruggabletargetandbiomarkerdiscovery AT lisapool roleofmitochondrialdysfunctioninatrialfibrillationtranslationtodruggabletargetandbiomarkerdiscovery AT leonoorfjmwijdeveld roleofmitochondrialdysfunctioninatrialfibrillationtranslationtodruggabletargetandbiomarkerdiscovery AT natasjamsdegroot roleofmitochondrialdysfunctioninatrialfibrillationtranslationtodruggabletargetandbiomarkerdiscovery AT biancajjmbrundel roleofmitochondrialdysfunctioninatrialfibrillationtranslationtodruggabletargetandbiomarkerdiscovery |