GM-CSF increases mucosal and systemic immunogenicity of an H1N1 influenza DNA vaccine administered into the epidermis of non-human primates.

GM-CSF increases mucosal and systemic immunogenicity of an H1N1 influenza DNA vaccine administered into the epidermis of non-human primates.

The recent H5N1 avian and H1N1 swine-origin influenza virus outbreaks reaffirm that the threat of a world-wide influenza pandemic is both real and ever-present. Vaccination is still considered the best strategy for protection against influenza virus infection but a significant challenge is to identi...

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Bibliographic Details
Main Authors: Peter T Loudon, Eric J Yager, Debbie T Lynch, Amithi Narendran, Cristy Stagnar, Anthony M Franchini, James T Fuller, Phil A White, Julia Nyuandi, Clayton A Wiley, Michael Murphey-Corb, Deborah H Fuller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2882341?pdf=render

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