Impacts of ABCG2 loss of function variant (p. Gln141Lys, c.421 C > A, rs2231142) on lipid levels and statin efficiency: a systematic review and meta-analysis
Abstract Background The latest evidence indicates that ATP-binding cassette superfamily G member 2 (ABCG2) is critical in regulating lipid metabolism and mediating statin or cholesterol efflux. This study investigates whether the function variant loss within ABCG2 (rs2231142) impacts lipid levels an...
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-024-03821-2 |
| _version_ | 1827284487779647488 |
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| author | Yang Liu Yuan Chen Baozhu Wei Hang Li Yuanyuan Peng Zhi Luo |
| author_facet | Yang Liu Yuan Chen Baozhu Wei Hang Li Yuanyuan Peng Zhi Luo |
| author_sort | Yang Liu |
| collection | DOAJ |
| description | Abstract Background The latest evidence indicates that ATP-binding cassette superfamily G member 2 (ABCG2) is critical in regulating lipid metabolism and mediating statin or cholesterol efflux. This study investigates whether the function variant loss within ABCG2 (rs2231142) impacts lipid levels and statin efficiency. Methods PubMed, Cochrane Library, Central, CINAHL, and ClinicalTrials.gov were searched until November 18, 2023. Results Fifteen studies (34,150 individuals) were included in the analysis. The A allele [Glu141Lys amino acid substitution was formed by a transversion from cytosine (C) to adenine (A)] of rs2231142 was linked to lower levels of high-density lipoprotein cholesterol (HDL-C), and higher levels of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC). In addition, the A allele of rs2231142 substantially increased the lipid-lowering efficiency of rosuvastatin in Asian individuals with dyslipidemia. Subgroup analysis indicated that the impacts of rs2231142 on lipid levels and statin response were primarily in Asian individuals. Conclusions The ABCG2 rs2231142 loss of function variant significantly impacts lipid levels and statin efficiency. Preventive use of rosuvastatin may prevent the onset of coronary artery disease (CAD) in Asian individuals with dyslipidemia. |
| first_indexed | 2024-04-24T09:56:01Z |
| format | Article |
| id | doaj.art-06dbe264636040fc80d80e175a11685e |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-24T09:56:01Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-06dbe264636040fc80d80e175a11685e2024-04-14T11:07:17ZengBMCBMC Cardiovascular Disorders1471-22612024-04-012411810.1186/s12872-024-03821-2Impacts of ABCG2 loss of function variant (p. Gln141Lys, c.421 C > A, rs2231142) on lipid levels and statin efficiency: a systematic review and meta-analysisYang Liu0Yuan Chen1Baozhu Wei2Hang Li3Yuanyuan Peng4Zhi Luo5Department of Endocrinology, China Resources and WISCO General HospitalDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan UniversityDepartment of Geratology, Zhongnan Hospital of Wuhan University, Wuhan UniversityDepartment of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan UniversityDepartment of Cardiology, Suining Central HospitalAbstract Background The latest evidence indicates that ATP-binding cassette superfamily G member 2 (ABCG2) is critical in regulating lipid metabolism and mediating statin or cholesterol efflux. This study investigates whether the function variant loss within ABCG2 (rs2231142) impacts lipid levels and statin efficiency. Methods PubMed, Cochrane Library, Central, CINAHL, and ClinicalTrials.gov were searched until November 18, 2023. Results Fifteen studies (34,150 individuals) were included in the analysis. The A allele [Glu141Lys amino acid substitution was formed by a transversion from cytosine (C) to adenine (A)] of rs2231142 was linked to lower levels of high-density lipoprotein cholesterol (HDL-C), and higher levels of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC). In addition, the A allele of rs2231142 substantially increased the lipid-lowering efficiency of rosuvastatin in Asian individuals with dyslipidemia. Subgroup analysis indicated that the impacts of rs2231142 on lipid levels and statin response were primarily in Asian individuals. Conclusions The ABCG2 rs2231142 loss of function variant significantly impacts lipid levels and statin efficiency. Preventive use of rosuvastatin may prevent the onset of coronary artery disease (CAD) in Asian individuals with dyslipidemia.https://doi.org/10.1186/s12872-024-03821-2ABCG2rs2231142DyslipidemiaStatinCoronary artery disease |
| spellingShingle | Yang Liu Yuan Chen Baozhu Wei Hang Li Yuanyuan Peng Zhi Luo Impacts of ABCG2 loss of function variant (p. Gln141Lys, c.421 C > A, rs2231142) on lipid levels and statin efficiency: a systematic review and meta-analysis BMC Cardiovascular Disorders ABCG2 rs2231142 Dyslipidemia Statin Coronary artery disease |
| title | Impacts of ABCG2 loss of function variant (p. Gln141Lys, c.421 C > A, rs2231142) on lipid levels and statin efficiency: a systematic review and meta-analysis |
| title_full | Impacts of ABCG2 loss of function variant (p. Gln141Lys, c.421 C > A, rs2231142) on lipid levels and statin efficiency: a systematic review and meta-analysis |
| title_fullStr | Impacts of ABCG2 loss of function variant (p. Gln141Lys, c.421 C > A, rs2231142) on lipid levels and statin efficiency: a systematic review and meta-analysis |
| title_full_unstemmed | Impacts of ABCG2 loss of function variant (p. Gln141Lys, c.421 C > A, rs2231142) on lipid levels and statin efficiency: a systematic review and meta-analysis |
| title_short | Impacts of ABCG2 loss of function variant (p. Gln141Lys, c.421 C > A, rs2231142) on lipid levels and statin efficiency: a systematic review and meta-analysis |
| title_sort | impacts of abcg2 loss of function variant p gln141lys c 421 c a rs2231142 on lipid levels and statin efficiency a systematic review and meta analysis |
| topic | ABCG2 rs2231142 Dyslipidemia Statin Coronary artery disease |
| url | https://doi.org/10.1186/s12872-024-03821-2 |
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