Impacts of ABCG2 loss of function variant (p. Gln141Lys, c.421 C > A, rs2231142) on lipid levels and statin efficiency: a systematic review and meta-analysis

Impacts of ABCG2 loss of function variant (p. Gln141Lys, c.421 C > A, rs2231142) on lipid levels and statin efficiency: a systematic review and meta-analysis

Abstract Background The latest evidence indicates that ATP-binding cassette superfamily G member 2 (ABCG2) is critical in regulating lipid metabolism and mediating statin or cholesterol efflux. This study investigates whether the function variant loss within ABCG2 (rs2231142) impacts lipid levels an...

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Bibliographic Details
Main Authors: Yang Liu, Yuan Chen, Baozhu Wei, Hang Li, Yuanyuan Peng, Zhi Luo
Format: Article
Language:English
Published: BMC 2024-04-01
Series:BMC Cardiovascular Disorders
Subjects:
ABCG2
rs2231142
Dyslipidemia
Statin
Coronary artery disease
Online Access:https://doi.org/10.1186/s12872-024-03821-2

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