Scleroderma Associated with Monoclonal Gammopathy of Undetermined Significance
Abstract A 53-year-old female presented with itchiness in her back. She has a 5 years history of tightness of the skin on her face, neck, and torso bilaterally. She did not have other symptoms suggestive of systemic sclerosis (scleroderma), and her rheumatologic workup was negative. Skin biopsy show...
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| Format: | Article |
| Language: | English |
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Knowledge E
2022-12-01
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| Series: | Sudan Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.18502/sjms.v17i4.12553 |
| _version_ | 1797959947248467968 |
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| author | Dalya M. M. Abdelmaged Carol A. Avila Michelle A. Rivera Abubaker A. Mohamedsharif |
| author_facet | Dalya M. M. Abdelmaged Carol A. Avila Michelle A. Rivera Abubaker A. Mohamedsharif |
| author_sort | Dalya M. M. Abdelmaged |
| collection | DOAJ |
| description | Abstract A 53-year-old female presented with itchiness in her back. She has a 5 years history of tightness of the skin on her face, neck, and torso bilaterally. She did not have other symptoms suggestive of systemic sclerosis (scleroderma), and her rheumatologic workup was negative. Skin biopsy showed increased dermal mucin confirming a diagnosis of scleredema. Further workup with serum protein electrophoresis (SPEP) showed an M-spike, confirming the diagnosis of monoclonal gammopathy of undetermined significance MGUS as the underlying pathology. |
| first_indexed | 2024-04-11T00:38:46Z |
| format | Article |
| id | doaj.art-06dc2f2c5ad54e2293cfcfabf895b2e6 |
| institution | Directory Open Access Journal |
| issn | 1858-5051 |
| language | English |
| last_indexed | 2024-04-11T00:38:46Z |
| publishDate | 2022-12-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Sudan Journal of Medical Sciences |
| spelling | doaj.art-06dc2f2c5ad54e2293cfcfabf895b2e62023-01-06T10:23:13ZengKnowledge ESudan Journal of Medical Sciences1858-50512022-12-0117455656410.18502/sjms.v17i4.12553sjms.v17i4.12553Scleroderma Associated with Monoclonal Gammopathy of Undetermined SignificanceDalya M. M. Abdelmaged0Carol A. Avila1Michelle A. Rivera2Abubaker A. Mohamedsharif3 MD, Faculty of Medicine, Al Neelain University, Khartoum, Sudan Universidad de Carabobo, Valencia, Venezuela Weill Cornell Medicine, USA Weill Cornell Medicine, USA Faculty of Medicine, University of Khartoum, Khartoum, SudanAbstract A 53-year-old female presented with itchiness in her back. She has a 5 years history of tightness of the skin on her face, neck, and torso bilaterally. She did not have other symptoms suggestive of systemic sclerosis (scleroderma), and her rheumatologic workup was negative. Skin biopsy showed increased dermal mucin confirming a diagnosis of scleredema. Further workup with serum protein electrophoresis (SPEP) showed an M-spike, confirming the diagnosis of monoclonal gammopathy of undetermined significance MGUS as the underlying pathology.https://doi.org/10.18502/sjms.v17i4.12553serum protein electrophoresis (spep), monoclonal gammopathy of undetermined significance (mgus), double-stranded dna (dsdna), antinuclear antibodies immunoglobulin g (ana igg), anti-sjogren's syndrome (ssb), anti-topoisomerase antibody-type (scl), ribonucleic acid (rna), cyclic citrullinated peptide (ccp), u1 small nuclear ribonucleoprotein particle (u1 rnp), multiple myeloma (mm), immunomodulatory drugs (imids), proteasome inhibitors (pis), intravenous immunoglobulins (ivig) |
| spellingShingle | Dalya M. M. Abdelmaged Carol A. Avila Michelle A. Rivera Abubaker A. Mohamedsharif Scleroderma Associated with Monoclonal Gammopathy of Undetermined Significance Sudan Journal of Medical Sciences serum protein electrophoresis (spep), monoclonal gammopathy of undetermined significance (mgus), double-stranded dna (dsdna), antinuclear antibodies immunoglobulin g (ana igg), anti-sjogren's syndrome (ssb), anti-topoisomerase antibody-type (scl), ribonucleic acid (rna), cyclic citrullinated peptide (ccp), u1 small nuclear ribonucleoprotein particle (u1 rnp), multiple myeloma (mm), immunomodulatory drugs (imids), proteasome inhibitors (pis), intravenous immunoglobulins (ivig) |
| title | Scleroderma Associated with Monoclonal Gammopathy of Undetermined Significance |
| title_full | Scleroderma Associated with Monoclonal Gammopathy of Undetermined Significance |
| title_fullStr | Scleroderma Associated with Monoclonal Gammopathy of Undetermined Significance |
| title_full_unstemmed | Scleroderma Associated with Monoclonal Gammopathy of Undetermined Significance |
| title_short | Scleroderma Associated with Monoclonal Gammopathy of Undetermined Significance |
| title_sort | scleroderma associated with monoclonal gammopathy of undetermined significance |
| topic | serum protein electrophoresis (spep), monoclonal gammopathy of undetermined significance (mgus), double-stranded dna (dsdna), antinuclear antibodies immunoglobulin g (ana igg), anti-sjogren's syndrome (ssb), anti-topoisomerase antibody-type (scl), ribonucleic acid (rna), cyclic citrullinated peptide (ccp), u1 small nuclear ribonucleoprotein particle (u1 rnp), multiple myeloma (mm), immunomodulatory drugs (imids), proteasome inhibitors (pis), intravenous immunoglobulins (ivig) |
| url | https://doi.org/10.18502/sjms.v17i4.12553 |
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